Human immunodeficiency virus (HIV) has spread globally. Both acquired immune deficiency syndromes (AIDs) and its complications pose a serious threat to human health. Acupuncture has been reported as a complement to Western medicine for relieving HIV/AIDs-related symptoms, but systematic reviews on acupuncture for HIV/AIDs and its complications are lacking. Six databases were searched for both randomized controlled trials (RCTs) and quasi-randomized controlled trials (q-RCTs) using any types of acupuncture for HIV/AIDs and their complications. The primary outcome included global clinical efficacy assessment (i.e., number of patients with improving symptoms), pain, numbness intensity, sleep quality, depression and severe adverse events (i.e., death or hospitalization), and the secondary outcomes included other HIV/AIDs related outcomes such as immune response markers (CD4+ -lymphocyte count), biochemical markers, functional outcomes (quality of life, level of physical activity), follow-ups and other adverse outcomes such as nausea, vomiting, and fever. Two reviewers independently applied the inclusion criteria, extracted data and evaluated the risk of bias in the included trials. This systematic review is registered with PROSPERO (CRD42020214490). Sixteen trials (thirteen RCTs and three q-RCTs) on complications including peripheral neuropathy, gastrointestinal symptoms, inflammation, insomnia and depression were included. The results revealed that manual acupuncture plus moxibustion (RR 1.58, 95 % CI [1.10, 2.28], 1 RCT, = 60), manual acupuncture only (RR 1.56, 95 % CI [1.20, 2.03], 1 RCT, 1 q-RCT, = 175) or auricular acupuncture (RR 2.02, 95 % CI [1.35, 3.02], 1 RCT, = 72) could improve the symptoms in HIV-infected patients; reduce pain and numbness intensity, reduce score of Hamilton Depression Scale andimprove sleep quality. Meanwhile, acupuncture appeared to improve biochemical indicators whilst not increasing the drop-out rate, recurrence, mortality or adverse events. The quality of evidence was moderate quality for sleep quality; low quality for global clinical efficacy assessment rate, pain and numbness intensity; and very low quality for pain and depression. Acupuncture may be an effective and safe intervention for HIV/AIDs related complications, including peripheral neuropathy, inflammation, insomnia and depression. However, the low quality of the evidence limits the relevance of those findings.

中文翻译：

---

针灸治疗艾滋病毒/艾滋病及其并发症：系统评价和荟萃分析

人类免疫缺陷病毒（HIV）已在全球传播。获得性免疫缺陷综合症（AID）及其并发症对人类健康构成严重威胁。据报道，针灸可作为西药的补充来缓解艾滋病毒/艾滋病相关症状，但缺乏对针灸治疗艾滋病毒/艾滋病及其并发症的系统评价。检索了六个数据库中使用任何类型的针灸治疗艾滋病毒/艾滋病及其并发症的随机对照试验 (RCT) 和半随机对照试验 (q-RCT)。主要结局包括总体临床疗效评估（即症状改善的患者数量）、疼痛、麻木强度、睡眠质量、抑郁和严重不良事件（即死亡或住院），次要结局包括其他与艾滋病毒/艾滋病相关的疾病免疫反应标记物（CD4+淋巴细胞计数）、生化标记物、功能性结果（生活质量、体力活动水平）、随访和其他不良结果（例如恶心、呕吐和发烧）等结果。两名评审员独立应用纳入标准、提取数据并评估纳入试验的偏倚风险。该系统评价已在 PROSPERO 注册（CRD42020214490）。纳入了 16 项关于并发症（包括周围神经病变、胃肠道症状、炎症、失眠和抑郁）的试验（13 项随机对照试验和 3 项随机对照试验）。结果显示，手工针灸加艾灸（RR 1.58，95 % CI [1.10，2.28]，1 个 RCT，= 60），仅手工针灸（RR 1.56，95 % CI [1.20，2.03]，1 个 RCT，1 q- RCT，= 175）或耳针（RR 2.02，95 % CI [1.35，3.02]，1 RCT，= 72）可以改善 HIV 感染者的症状；减轻疼痛和麻木强度，降低汉密尔顿抑郁量表评分，改善睡眠质量。与此同时，针灸似乎可以改善生化指标，同时不会增加退出率、复发率、死亡率或不良事件。睡眠质量的证据质量为中等；全球临床疗效评估率、疼痛麻木强度质量低；疼痛和抑郁的质量非常低。针灸可能是治疗艾滋病毒/艾滋病相关并发症的有效且安全的干预措施，包括周围神经病变、炎症、失眠和抑郁。然而，证据质量低限制了这些发现的相关性。