Forensic analysis can encompass a wide variety of analytes from biological samples including DNA, blood, serum, and fingerprints to synthetic samples like drugs and explosives. In order to analyze this variety, there are various sample preparation techniques, which can be time-consuming and require multiple analytical instruments. With recent advancements in ambient ionization mass spectrometry (MS), plasma-based dielectric barrier discharge ionization (DBDI) sources have demonstrated to cover a wide range of these analytes. The flow-through design of this source also allows for easy connection to a thermal desorption type of sample introduction. We present an in-house built thermal desorption device where the sample is introduced via a glass slide, which gets heated and transferred to the DBDI-MS with nitrogen for identification and semi-quantification. Using a glass slide as an inexpensive sampling device, detection limits as low as 20 pg for fentanyl are demonstrated. Additionally, a very precise (>96% accuracy) identification of persons based on the chemical profile of their fingerprints is possible, establishing a direct analytical link of the drug trace to the individual in one measurement. We compared the DAG, TAG, sterol, and (semi-)volatile region of the averaged fingerprint spectra over multiple days, showing the best model accuracy for identification based on the DAG region. The combination of thermal desorption and DBDI-MS minimized sample preparation, leading to an ultrasensitive and rapid analysis of illicit drug traces and the identification of underlying personas based on fingerprints.

中文翻译：

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通过 SICRIT 离子源快速解吸和分析非法药物以及指纹的化学分析

法医分析可涵盖多种分析物，从生物样本（包括 DNA、血液、血清和指纹）到合成样本（如毒品和爆炸物）。为了分析该品种，有多种样品制备技术，这些技术可能非常耗时并且需要多种分析仪器。随着环境电离质谱 (MS) 的最新进展，基于等离子体的介质阻挡放电电离 (DBDI) 源已被证明可以覆盖广泛的这些分析物。该源的流通式设计还可以轻松连接到热解吸类型的样品引入。我们提出了一种内部构建的热解吸装置，其中样品通过载玻片引入，载玻片被加热并用氮气转移到 DBDI-MS 进行识别和半定量。使用载玻片作为廉价的采样装置，芬太尼的检测限低至 20 pg。此外，还可以根据指纹的化学特征对人员进行非常精确（>96% 的准确度）识别，从而在一次测量中建立药物痕迹与个人的直接分析联系。我们比较了多天平均指纹光谱的 DAG、TAG、甾醇和（半）挥发性区域，显示了基于 DAG 区域的最佳识别模型精度。热解吸和 DBDI-MS 的结合最大限度地减少了样品制备，从而可以对非法药物痕迹进行超灵敏且快速的分析，并根据指纹识别潜在的人物角色。