Background

Postoperative pancreatic fistula (POPF) is a severe complication following a pancreatoduodenectomy. An accurate prediction of POPF could assist the surgeon in offering tailor-made treatment decisions. The use of radiomic features has been introduced to predict POPF. A systematic review was conducted to evaluate the performance of models predicting POPF using radiomic features and to systematically evaluate the methodological quality.

Methods

Studies with patients undergoing a pancreatoduodenectomy and radiomics analysis on computed tomography or magnetic resonance imaging were included. Methodological quality was assessed using the Radiomics Quality Score (RQS) and Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis (TRIPOD) statement.

Results

Seven studies were included in this systematic review, comprising 1300 patients, of whom 364 patients (28 %) developed POPF. The area under the curve (AUC) of the included studies ranged from 0.76 to 0.95. Only one study externally validated the model, showing an AUC of 0.89 on this dataset. Overall adherence to the RQS (31 %) and TRIPOD guidelines (54 %) was poor.

Conclusion

This systematic review showed that high predictive power was reported of studies using radiomic features to predict POPF. However, the quality of most studies was poor. Future studies need to standardize the methodology.

Registration

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中文翻译：

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放射组学用于预测胰十二指肠切除术后胰瘘：系统评价和放射组学评分质量评估

背景

术后胰瘘（POPF）是胰十二指肠切除术后的严重并发症。准确预测 POPF 可以帮助外科医生提供量身定制的治疗决策。已引入放射组学特征的使用来预测 POPF。进行了系统评价，以评估使用放射组学特征预测 POPF 的模型的性能，并系统地评估方法学质量。

方法

包括对接受胰十二指肠切除术的患者进行的研究以及计算机断层扫描或磁共振成像的放射组学分析。使用放射组学质量评分 (RQS) 和个体预后或诊断多变量预测模型透明报告 (TRIPOD) 声明来评估方法学质量。

结果

本次系统评价纳入了 7 项研究，涉及 1300 名患者，其中 364 名患者 (28%) 出现 POPF。纳入研究的曲线下面积 (AUC) 范围为 0.76 至 0.95。只有一项研究从外部验证了该模型，显示该数据集的 AUC 为 0.89。对 RQS (31%) 和 TRIPOD 指南 (54%) 的总体遵守情况较差。

结论

该系统评价表明，使用放射组学特征预测 POPF 的研究具有较高的预测能力。然而，大多数研究的质量很差。未来的研究需要标准化方法。

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