当前位置：
X-MOL 学术
›
J. Sport Health Sci.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Does ergogenic effect of caffeine supplementation depend on CYP1A2 genotypes? A systematic review with meta-analysis
Journal of Sport and Health Science ( IF 11.7 ) Pub Date : 2023-12-28 , DOI: 10.1016/j.jshs.2023.12.005 Jieping Wang , Luthfia Dewi , Yundong Peng , Chien-Wen Hou , Yanmin Song , Giancarlo Condello
Journal of Sport and Health Science ( IF 11.7 ) Pub Date : 2023-12-28 , DOI: 10.1016/j.jshs.2023.12.005 Jieping Wang , Luthfia Dewi , Yundong Peng , Chien-Wen Hou , Yanmin Song , Giancarlo Condello
|
The ergogenic effects of caffeine intake on exercise performance are well-established, even if differences exist among individuals in response to caffeine intake. The genetic variation of a specific gene, human cytochrome P450 enzyme 1A2 () (rs762551), may be one reason for this difference. This systematic review and meta-analysis aimed to comprehensively evaluate the influence of gene types on athletes' exercise performance after caffeine intake. A literature search through 4 databases (Web of Science, PubMed, Scopus, and China National Knowledge Infrastructure) was conducted until March 2023. The effect size was expressed as the weighted mean difference (WMD) by calculating fixed effects meta-analysis if heterogeneity was not significant ( ≤ 50% and ≥ 0.1). Subgroup analyses were performed based on AA and AC/CC genotype of . The final number of studies meeting the inclusion criteria was 12 ( = 666 participants). The overall analysis showed that the cycling time trial significantly improved after caffeine intake (WMD = –0.48, 95% confidence interval (95%CI): –0.83 to –0.13, = 0.007). In subgroup analyses, acute caffeine intake improved cycling time trial only in individuals with the A allele (WMD = –0.90, 95%CI: –1.48 to –0.33, = 0.002), but not the C allele (WMD = –0.08, 95%CI: –0.32 to 0.17, = 0.53). Caffeine supplementation did not influence the Wingate (WMD = 8.07, 95%CI: –22.04 to 38.18, = 0.60) or countermovement jump test (CMJ) performance (WMD = 1.17, 95%CI: –0.02 to 2.36, = 0.05), and these outcomes were not influenced by . Participants with the with A allele improved their cycling time trials after caffeine supplementation. However, compared to placebo, acute caffeine supplementation failed to increase the Wingate or CMJ performance, regardless of .
更新日期：2023-12-28
京公网安备 11010802027423号