A strategy for the detection of benzodiazepine drugs using low-resolution paper-spray mass spectrometry for harm reduction drug checking,Drug Testing and Analysis

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A strategy for the detection of benzodiazepine drugs using low-resolution paper-spray mass spectrometry for harm reduction drug checking
Drug Testing and Analysis ( IF 2.6 ) Pub Date : 2023-12-25 , DOI: 10.1002/dta.3630
Allie Miskulin ₁ , Bruce Wallace _{2,

3} , Chris Gill _{1,

3,

4,

5,

6} , Dennis Hore _{1,

3,

7}

Affiliation

The ability to detect newly emerging substances is of great importance in reducing harms for people who use drugs. New psychoactive substances including novel benzodiazepines in the illicit drug supply have been linked to high rates of overdose deaths while complicating drug checking as an overdose prevention strategy. Paper-spray mass spectrometry (PS-MS) has emerged as a novel strategy to rapidly detect trace components in street drug samples. While targeted, low-resolution PS-MS methods have proven effective, newly emerging substances are often missed. To address this, a method was applied to low-resolution full-scan PS-MS data to aid in the early detection and identification of novel benzodiazepines in the unregulated drug supply. Using the developed method, true positives rates of 0.89 and 0.75 were achieved for bromazolam and etizolam in street samples obtained in a community drug checking service. The applicability of the method was further demonstrated for a novel benzodiazepine, desalkylgidazepam, that has recently emerged in the illicit drug supply.

中文翻译：

使用低分辨率纸喷雾质谱法检测苯二氮卓类药物以进行减害药物检查的策略

检测新出现的物质的能力对于减少吸毒者的伤害非常重要。非法药物供应中的新型精神活性物质（包括新型苯二氮卓类药物）与药物过量死亡率高有关，同时使药物检查作为药物过量预防策略变得复杂化。纸喷雾质谱法 (PS-MS) 已成为一种快速检测街头毒品样品中痕量成分的新策略。虽然靶向、低分辨率 PS-MS 方法已被证明是有效的，但经常会错过新出现的物质。为了解决这个问题，我们将一种方法应用于低分辨率全扫描 PS-MS 数据，以帮助早期检测和识别不受监管的药物供应中的新型苯二氮卓类药物。使用所开发的方法，在社区药物检查服务处获得的街道样本中，溴马唑仑和依替唑仑的真阳性率分别为 0.89 和 0.75。该方法的适用性进一步证明了最近在非法药物供应中出现的新型苯二氮卓类药物去烷基吉达西泮的适用性。

更新日期：2023-12-26

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