The design and development of advanced drug delivery systems targeting reactive oxygen species (ROS) have gained significant interest in recent years for treating various diseases, including cancer, psychiatric diseases, cardiovascular diseases, neurological diseases, metabolic diseases, and chronic inflammations. Integrating specific chemical bonds capable of effectively responding to ROS and triggering drug release into the delivery system is crucial. In this Review, we discuss commonly used conjugation linkers (chemical bonds) and categorize them into two groups: cleavable linkers and noncleavable linkers. Our goal is to clarify their unique drug release mechanisms from a chemical perspective and provide practical organic synthesis approaches for their efficient production. We showcase numerous significant examples to demonstrate their synthesis routes and diverse applications. Ultimately, we strive to present a comprehensive overview of cleavage and noncleavage chemistry, offering insights into the development of smart drug delivery systems that respond to ROS.

中文翻译：

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用于智能药物输送的活性氧 (ROS) 响应材料中的裂解和非裂解化学

近年来，针对活性氧（ROS）的先进药物递送系统的设计和开发在治疗各种疾病方面引起了极大的兴趣，包括癌症、精神疾病、心血管疾病、神经系统疾病、代谢疾病和慢性炎症。将能够有效响应 ROS 并触发药物释放到递送系统中的特定化学键整合起来至关重要。在本综述中，我们讨论了常用的缀合连接子（化学键）并将其分为两类：可切割连接子和不可切割连接子。我们的目标是从化学角度阐明其独特的药物释放机制，并为其高效生产提供实用的有机合成方法。我们展示了许多重要的例子来展示它们的合成路线和多样化的应用。最终，我们努力全面概述裂解和非裂解化学，为响应 ROS 的智能药物输送系统的开发提供见解。