Aptamers have emerged as research hotspots of the next generation due to excellent performance benefits and application potentials in pharmacology, medicine, and analytical chemistry. Despite the numerous aptamer investigations, the lack of comprehensive data integration has hindered the development of computational methods for aptamers and the reuse of aptamers. A public access database named AptaDB, derived from experimentally validated data manually collected from the literature, was hence developed, integrating comprehensive aptamer-related data, which include six key components: (i) experimentally validated aptamer–target interaction information, (ii) aptamer property information, (iii) structure information of aptamer, (iv) target information, (v) experimental activity information, and (vi) algorithmically calculated similar aptamers. AptaDB currently contains 1350 experimentally validated aptamer–target interactions, 1230 binding affinity constants, 1293 aptamer sequences, and more. Compared to other aptamer databases, it contains twice the number of entries found in available databases. The collection and integration of the above information categories is unique among available aptamer databases and provides a user-friendly interface. AptaDB will also be continuously updated as aptamer research evolves. We expect that AptaDB will become a powerful source for aptamer rational design and a valuable tool for aptamer screening in the future. For access to AptaDB, please visit http://lmmd.ecust.edu.cn/aptadb/.

中文翻译：

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AptaDB：集成适体-靶标相互作用的综合数据库

适体由于其优异的性能优势以及在药理学、医学和分析化学领域的应用潜力，已成为下一代研究热点。尽管进行了大量的适配体研究，但缺乏全面的数据集成阻碍了适配体计算方法的发展和适配体的重复利用。因此，开发了一个名为 AptaDB 的公共访问数据库，该数据库源自手动从文献中收集的经实验验证的数据，整合了与适体相关的全面数据，其中包括六个关键组成部分：（i）经实验验证的适体-靶点相互作用信息，（ii）适体属性信息，(iii) 适体的结构信息，(iv) 目标信息，(v) 实验活动信息，以及 (vi) 算法计算出的相似适体。 AptaDB 目前包含 1350 个经过实验验证的适体-靶标相互作用、1230 个结合亲和常数、1293 个适体序列等。与其他适体数据库相比，它包含的条目数量是可用数据库中发现的条目数量的两倍。上述信息类别的收集和整合在现有适体数据库中是独一无二的，并提供了用户友好的界面。 AptaDB也将随着适配体研究的进展而不断更新。我们期望AptaDB未来将成为适体合理设计的强大来源和适体筛选的宝贵工具。如需访问AptaDB，请访问http://lmmd.ecust.edu.cn/aptadb/。