In recent decades, environmental concerns have directed several policies, investments, and production processes. The search for sustainable and eco-friendly strategies is constantly increasing to reduce petrochemical product utilization, fossil fuel pollution, waste generation, and other major ecological impacts. The concepts of circular economy, bioeconomy, and biorefinery are increasingly being applied to solve or reduce those problems, directing us towards a greener future. Within the biotechnology field, the Bacillus genus of bacteria presents extremely versatile microorganisms capable of producing a great variety of products with little to no dependency on petrochemicals. They are able to grow in different agro-industrial wastes and extreme conditions, resulting in healthy and environmentally friendly products, such as foods, feeds, probiotics, plant growth promoters, biocides, enzymes, and bioactive compounds. The objective of this review was to compile the variety of products that can be produced with Bacillus cells, using the concepts of biorefinery and circular economy as the scope to search for greener alternatives to each production method and providing market and bioeconomy ideas of global production. Although the genus is extensively used in industry, little information is available on its large-scale production, and there is little current data regarding bioeconomy and circular economy parameters for the bacteria. Therefore, as this work gathers several products' economic, production, and environmentally friendly use information, it can be addressed as one of the first steps towards those sustainable strategies. Additionally, an extensive patent search was conducted, focusing on products that contain or are produced by the Bacillus genus, providing an indication of global technology development and direction of the bacteria products. The Bacillus global market represented at least $18 billion in 2020, taking into account only the products addressed in this article, and at least 650 patent documents submitted per year since 2017, indicating this market's extreme importance. The data we provide in this article can be used as a base for further studies in bioeconomy and circular economy and show the genus is a promising candidate for a greener and more sustainable future.

近几十年来，环境问题影响了多项政策、投资和生产流程。人们不断寻求可持续和生态友好的战略，以减少石化产品的使用、化石燃料污染、废物产生和其他主要生态影响。循环经济、生物经济和生物精炼的概念越来越多地被应用于解决或减少这些问题，引导我们走向更加绿色的未来。在生物技术领域，芽孢杆菌属细菌是用途极其广泛的微生物，能够生产多种产品，几乎不依赖石化产品。它们能够在不同的农工业废物和极端条件下生长，产生健康环保的产品，如食品、饲料、益生菌、植物生长促进剂、杀菌剂、酶和生物活性化合物。本次审查的目的是汇编可用芽孢杆菌细胞生产的各种产品，以生物精炼和循环经济的概念为范围，寻找每种生产方法的更绿色替代品，并提供全球生产的市场和生物经济理念。尽管该属在工业中被广泛使用，但有关其大规模生产的信息很少，并且关于该细菌的生物经济和循环经济参数的当前数据也很少。因此，由于这项工作收集了多种产品的经济、生产和环保使用信息，因此可以将其视为实现这些可持续战略的第一步。此外，还进行了广泛的专利检索，重点关注含有芽孢杆菌属或由芽孢杆菌属生产的产品，为细菌产品的全球技术发展和方向提供了指示。仅考虑本文中涉及的产品，以及自 2017 年以来每年至少提交 650 份专利文件，到 2020 年，芽孢杆菌全球市场至少达到 180 亿美元，表明该市场极其重要。我们在本文中提供的数据可以用作生物经济和循环经济进一步研究的基础，并表明该属是实现更绿色和更可持续的未来的有希望的候选者。