Summary: Rowe and colleagues discover that one-carbon (1C) metabolism rewiring occurs upon T-cell activation to support proliferation and cytolytic activity in CD8+ T cells and that supplementation of 1C donor formate rescues the dysfunctional T cells and their responsiveness to anti–PD-1 in selective tumor-infiltrated T-cell subsets. This finding represents an attractive strategy to overcome a metabolic vulnerability in the tumor microenvironment and improve the efficacy of immune checkpoint blockade. See related article by Rowe et al., p. 2566 (8).

中文翻译：

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重新“形成”T 细胞抗肿瘤反应


摘要：Rowe 及其同事发现，T 细胞激活时会发生一碳 (1C) 代谢重连，以支持 CD8+ T 细胞的增殖和细胞溶解活性，并且补充 1C 供体甲酸盐可挽救功能失调的 T 细胞及其对抗 PD 的反应。 -1 在选择性肿瘤浸润 T 细胞亚群中。这一发现代表了一种有吸引力的策略，可以克服肿瘤微环境中的代谢脆弱性并提高免疫检查点阻断的功效。请参阅 Rowe 等人的相关文章，第 17 页。 2566（8）。