INTRODUCTION Familial adenomatous polyposis (FAP) is an autosomal, dominantly inherited disorder that predisposes to colorectal cancer. An increased risk of cancer may affect mental health, but the magnitude of this effect remains unknown. We assessed the psychosocial functioning, including the educational level attained and risk of psychiatric comorbidity, of FAP patients by comparing them with matched non-exposed individuals. METHODS All Danish FAP patients diagnosed before April 2021 were identified in the Danish Polyposis Register and paired with four matched non-exposed. Educational history, psychiatric contacts or diagnoses (ICD-10), and treatment with antidepressants, anxiolytics, or antipsychotics were compared between FAP patients and non-exposed. RESULTS The analysis included 445 FAP patients and 1,538 non-exposed. The highest educational level reached was significantly lower for FAP patients ( p <0.001). When comparing FAP patients and non-exposed and adjusting for a cancer diagnosis, an increased risk was observed for a psychiatric contact (1.69, CI 95%, 1.25-2.29, p <0.001), any psychiatric prescription (1.39, CI 95%, 1.17-1.66, p <0.001), a psychiatric diagnosis (1.64, CI 95%, 1.19-2.26, p =0.002), and experiencing any psychiatric event (HR 1.42, CI 95%, 1.20-1.68, p <0.001). An increased risk was specifically seen for mood (affective) disorders (1.76, CI 95%, 1.09-2.83, p =0.02) and behavioural and emotional disorders (2.01, CI 95%, 1.10-3.69, p =0.02), as well as the need for antidepressants (1.59, CI 95%, 1.24-2.03, p <0.001) and antipsychotics (1.85, CI 95%, 1.26-2.70, p =0.002). CONCLUSION Compared to non-exposed individuals, FAP patients had significantly less education and an increased risk of developing mood and behavioural disorders, with an increased likelihood of needing antidepressants and antipsychotics.

中文翻译：

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家族性腺瘤性息肉病的精神病学和教育方面——一项针对匹配的非暴露个体的丹麦全国队列研究。

简介 家族性腺瘤性息肉病 (FAP) 是一种常染色体显性遗传性疾病，易患结直肠癌。癌症风险增加可能会影响心理健康，但这种影响的程度仍不清楚。我们通过将 FAP 患者与匹配的非暴露个体进行比较，评估了 FAP 患者的心理社会功能，包括所获得的教育水平和精神合并症的风险。方法 2021 年 4 月之前诊断的所有丹麦 FAP 患者均在丹麦息肉病登记册中进行识别，并与四名匹配的非暴露患者配对。对 FAP 患者和非暴露患者的教育史、精神病学接触或诊断 (ICD-10) 以及抗抑郁药、抗焦虑药或抗精神病药的治疗进行了比较。结果 分析包括 445 名 FAP 患者和 1,538 名未暴露患者。FAP 患者达到的最高教育水平显着较低 (p <0.001)。当比较 FAP 患者和未暴露患者并根据癌症诊断进行调整时，观察到精神科接触（1.69，CI 95%、1.25-2.29，p <0.001）、任何精神科处方（1.39，CI 95%， 1.17-1.66，p <0.001），精神科诊断（1.64，CI 95%，1.19-2.26，p = 0.002），并经历任何精神事件（HR 1.42，CI 95%，1.20-1.68，p <0.001）。情绪（情感）障碍（1.76，CI 95%，1.09-2.83，p = 0.02）以及行为和情绪障碍（2.01，CI 95%，1.10-3.69，p = 0.02）的风险尤其增加。与抗抑郁药（1.59，CI 95%，1.24-2.03，p <0.001）和抗精神病药（1.85，CI 95%，1.26-2.70，p = 0.002）的需求相同。结论 与非暴露个体相比，FAP 患者受教育程度明显较低，出现情绪和行为障碍的风险增加，需要抗抑郁药物和抗精神病药物的可能性也增加。