This study assessed the prevalence of iron overload in infants born to Rh isoimmunized mothers. Infants born to Rh isoimmunized mothers with Indirect Coomb's Test (ICT) titers ≥1:16 were prospectively enrolled and followed until 3 mo. Hemoglobin and serum ferritin were estimated at birth and 3 mo of age. The outcomes were the incidence of iron overload (at birth and 3 mo), anemia, and the need for transfusions in the first 3 mo. Seventy-four infants were enrolled, nearly half receiving intrauterine transfusion (IUT). Sixty (82.2%) had hyperferritinemia at birth. The median (1st, 3rd quartile) ferritin levels were 456 (321, 631) μg/L. Infants who received IUTs had significantly higher serum ferritin levels at birth. Fifty-one (76.1%) infants had hyperferritinemia at 3 mo. Over three months of follow-up, 53 (71.6%) infants had anemia, of which 33 (48.5%) required packed red blood cells (PRBC) transfusion. These findings suggest that iron overload is common in these infants in the first 3 mo.

中文翻译：

---

新生儿恒河猴溶血病中的铁超载和贫血：一项前瞻性观察研究。

这项研究评估了 Rh 同种免疫母亲所生婴儿铁超载的患病率。间接库姆氏试验 (ICT) 滴度≥1:16 的 Rh 同种免疫母亲所生的婴儿被前瞻性地纳入并随访至 3 个月。在出生时和 3 个月大时评估血红蛋白和血清铁蛋白。结果是铁超负荷（出生时和 3 个月）、贫血的发生率以及前 3 个月内是否需要输血。共有 74 名婴儿入组，其中近一半接受宫内输血 (IUT)。60 人（82.2%）出生时患有高铁蛋白血症。中位（第一、第三四分位数）铁蛋白水平为 456（321、631）μg/L。接受 IUT 的婴儿出生时血清铁蛋白水平显着升高。51 名 (76.1%) 婴儿在 3 个月时患有高铁蛋白血症。经过三个月的随访，53 名（71.6%）婴儿患有贫血，其中 33 名（48.5%）需要输注浓缩红细胞（PRBC）。这些发现表明，这些婴儿在出生后 3 个月内铁超载很常见。