Background Optical coherence tomography angiography (OCTA) is an emerging imaging modality that enables noninvasive visualization and analysis of tumor vasculature. OCTA has been particularly useful in clinical ocular oncology, while in this article, we evaluated OCTA in assessing microvascular changes in clinical nonocular oncology through a systematic review of the literature. Method The inclusion criterion for the literature search in PubMed, Web of Science and Scopus electronic databases was the use of OCTA in nonocular clinical oncology, meaning that all ocular clinical studies and all ocular and nonocular animal, phantom, ex vivo, experimental, research and development, and purely methodological studies were excluded. Results Eleven articles met the inclusion criteria. The anatomic locations of the neoplasms in the selected articles were the gastrointestinal tract (2 articles), head and neck (1 article) and skin (8 articles). Conclusions While OCTA has shown great advancements in ophthalmology, its translation to the nonocular clinical oncology setting presents several limitations, with a lack of standardized protocols and interpretation guidelines posing the most significant challenge.

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通过光学相干断层扫描血管造影对非眼肿瘤临床应用中的微血管变化进行成像：文献综述

背景光学相干断层扫描血管造影（OCTA）是一种新兴的成像方式，可以对肿瘤脉管系统进行无创可视化和分析。OCTA 在临床眼部肿瘤学中特别有用，而在本文中，我们通过对文献的系统回顾，评估了 OCTA 在评估临床非眼部肿瘤学微血管变化方面的作用。方法 PubMed、Web of Science 和 Scopus 电子数据库文献检索的纳入标准是 OCTA 在非眼部临床肿瘤学中的使用，这意味着所有眼部临床研究以及所有眼部和非眼部动物、体模、离体、实验、研究和发展和纯粹的方法论研究被排除在外。结果 11 篇文章符合纳入标准。所选文章中肿瘤的解剖位置为胃肠道（2篇文章）、头颈部（1篇文章）和皮肤（8篇文章）。结论 虽然 OCTA 在眼科领域取得了巨大进步，但其向非眼科临床肿瘤学环境的转化存在一些局限性，缺乏标准化协议和解释指南构成了最重大的挑战。