Multispectral optoacoustic tomography (MSOT) allows non-invasive molecular disease activity assessment in adults with inflammatory bowel disease (IBD). In this prospective pilot-study, we investigated, whether increased levels of MSOT haemoglobin parameters corresponded to inflammatory activity in paediatric IBD patients, too. 23 children with suspected IBD underwent MSOT of the terminal ileum and sigmoid colon with standard validation (e.g. endoscopy). In Crohn`s disease (CD) and ulcerative colitis (UC) patients with endoscopically confirmed disease activity, MSOT total haemoglobin (HbT) signals were increased in the terminal ileum of CD (72.1 ± 13.0 a.u. vs. 32.9 ± 15.4 a.u., p = 0.0049) and in the sigmoid colon of UC patients (62.9 ± 13.8 a.u. vs. 35.1 ± 16.3 a.u., p = 0.0311) as compared to controls, respectively. Furthermore, MSOT haemoglobin parameters correlated well with standard disease activity assessment (e.g. SES-CD and MSOT HbT (r_s =0.69, p = 0.0075). Summarizing, MSOT is a novel technology for non-invasive molecular disease activity assessment in paediatric patients with inflammatory bowel disease.

多光谱光声断层扫描 (MSOT) 可以对成人炎症性肠病 (IBD) 进行非侵入性分子疾病活动性评估。在这项前瞻性预研究中，我们调查了 MSOT 血红蛋白参数水平的升高是否也与儿童 IBD 患者的炎症活动相对应。23 名疑似 IBD 儿童接受了回肠末端和乙状结肠 MSOT 并进行了标准验证（例如内窥镜检查）。在内窥镜证实患有疾病活动的克罗恩病 (CD) 和溃疡性结肠炎 (UC) 患者中，CD 回肠末端的 MSOT 总血红蛋白 (HbT) 信号增加（72.1 ± 13.0 au 与 32.9 ± 15.4 au，p =与对照组相比，UC 患者的乙状结肠（62.9 ± 13.8 au 与 35.1 ± 16.3 au，p = 0.0311）分别为 0.0049）和乙状结肠。此外，MSOT 血红蛋白参数与标准疾病活动度评估（例如 SES-CD 和 MSOT HbT（r _s =0.69，p = 0.0075））密切相关。总而言之，MSOT 是一种用于儿科患者非侵入性分子疾病活动度评估的新技术。炎症性肠病。