The Q-GAPS (Q fever GermAn interdisciplinary Program for reSearch) consortium was launched in 2017 as a German consortium of more than 20 scientists with exceptional expertise, competence, and substantial knowledge in the field of the Q fever pathogen Coxiella (C.) burnetii. C. burnetii exemplifies as a zoonotic pathogen the challenges of zoonotic disease control and prophylaxis in human, animal, and environmental settings in a One Health approach. An interdisciplinary approach to studying the pathogen is essential to address unresolved questions about the epidemiology, immunology, pathogenesis, surveillance, and control of C. burnetii. In more than five years, Q-GAPS has provided new insights into pathogenicity and interaction with host defense mechanisms. The consortium has also investigated vaccine efficacy and application in animal reservoirs and identified expanded phenotypic and genotypic characteristics of C. burnetii and their epidemiological significance. In addition, conceptual principles for controlling, surveilling, and preventing zoonotic Q fever infections were developed and prepared for specific target groups. All findings have been continuously integrated into a Web-based, interactive, freely accessible knowledge and information platform (www.q-gaps.de), which also contains Q fever guidelines to support public health institutions in controlling and preventing Q fever. In this review, we will summarize our results and show an example of how an interdisciplinary consortium provides knowledge and better tools to control a zoonotic pathogen at the national level.

Q-GAPS（Q 热德国跨学科研究计划）联盟于 2017 年成立，是一个由 20 多名在 Q 热病原体伯内特柯克斯体( C. )领域拥有卓越专业知识、能力和丰富知识的科学家组成的德国联盟。。伯内特隐球菌作为一种人畜共患病原体，体现了在“同一个健康”方法中在人类、动物和环境中控制和预防人畜共患疾病所面临的挑战。研究病原体的跨学科方法对于解决有关伯氏念珠菌的流行病学、免疫学、发病机制、监测和控制等尚未解决的问题至关重要。五年多来，Q-GAPS 为致病性以及与宿主防御机制的相互作用提供了新的见解。该联盟还研究了疫苗的功效和在动物宿主中的应用，并确定了伯内特念珠菌的扩展表型和基因型特征及其流行病学意义。此外，还为特定目标群体制定和准备了控制、监测和预防人畜共患 Q 热感染的概念原则。所有研究结果均不断整合到基于网络的、交互式的、可免费访问的知识和信息平台（www.q-gaps.de）中，该平台还包含 Q 热指南，以支持公共卫生机构控制和预防 Q 热。在这篇综述中，我们将总结我们的结果，并展示一个跨学科联盟如何提供知识和更好的工具来在国家层面控制人畜共患病原体的例子。