Mechanical ventilation is a lifesaving intervention that may also induce further lung injury by exerting excessive mechanical forces on susceptible lung tissue, a phenomenon termed ventilator-induced lung injury (VILI). The concept of mechanical power (MP) aims to unify in one single variable the contribution of the different ventilatory parameters that could induce VILI by measuring the energy transfer to the lung over time. Despite an increasing amount of evidence demonstrating that high MP values can be associated with VILI development in experimental studies, the evidence regarding the association of MP and clinical outcomes remains controversial. In the present review, we describe the different determinants of VILI, the concept and computation of MP, and discuss the experimental and clinical studies related to MP. Currently, due to different limitations, the clinical application of MP is debatable. Further clinical studies are required to enhance our understanding of the relationship between MP and the development of VILI, as well as its potential impact on clinical outcomes.

中文翻译：

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通气的机械功率：从计算机到临床意义。

机械通气是一种挽救生命的干预措施，但也可能通过对易受影响的肺组织施加过度的机械力而引发进一步的肺损伤，这种现象称为呼吸机诱发性肺损伤（VILI）。机械功率 (MP) 的概念旨在将不同通气参数的贡献统一在一个变量中，通过测量随时间推移向肺部传输的能量，这些参数可能诱发 VILI。尽管越来越多的证据表明，实验研究中高 MP 值可能与 VILI 的发展相关，但有关 MP 与临床结果之间关系的证据仍然存在争议。在本综述中，我们描述了 VILI 的不同决定因素、MP 的概念和计算，并讨论了与 MP 相关的实验和临床研究。目前，由于不同的局限性，MP的临床应用尚存争议。需要进一步的临床研究来增强我们对 MP 与 VILI 发展之间的关系及其对临床结果的潜在影响的理解。