IMPORTANCE Conservative therapy is effective for the treatment of overactive bladder (OAB) but may be limited by accessibility to care. OBJECTIVE The objective of this study was to evaluate the efficacy of a digital conversational agent (CeCe) for the treatment of OAB. STUDY DESIGN This was a prospective observational trial utilizing a digital conversational agent developed by Renalis University Hospitals (Cleveland, Ohio) for the treatment of OAB. Patients were given access to CeCe over an 8-week period and were instructed on how to perform bladder training and pelvic floor exercises and taught about bladder health. The primary outcome was a decrease in the International Consultation on Incontinence-Overactive Bladder Quality-of-Life Questionnaire (ICIQ-OAB-QoL) score from week 1 to week 8. Patients also completed the 36-item Short-Form Health Survey and Generalized Anxiety Disorder Questionnaire at the same intervals and voiding diaries at weeks 1, 4, and 8. A power analysis was performed and determined that a total of 30 patients would be needed to demonstrate a significant difference in symptom scores after use of CeCe with 80% power and an α error of 5%. RESULTS Twenty-nine patients completed all data collection. The ICIQ-OAB-QoL scores were significantly different between weeks 1 and 8 (62 [IQR], 49-75) vs 32 [IQR, 24-43]; P < 0.001). Patients also reported a decrease in frequency pretreatment and posttreatment (7 [IQR, 6-10] vs 5 [IQR, 4-7]; P = -0.04), nocturia (2 [IQR, 1-3] vs 1 [IQR, 1-2]; P = 0.03), and urge urinary incontinence (2 [IQR, 1-5] vs 0 [IQR, 0-3]; P = 0.04). Consumption of alcohol decreased from week 1 to week 8 (24 oz [IQR, 12-36 oz) to 14 oz (IQR, 9-22 oz]; P = 0.02). CONCLUSION The use of a digital conversational agent effectively reduced the severity of symptoms and improved quality of life in patients with OAB.

中文翻译：

---

使用数字会话代理来治疗膀胱过度活动症。

重要性 保守治疗对于治疗膀胱过度活动症 (OAB) 有效，但可能会受到护理可及性的限制。目的 本研究的目的是评估数字对话代理 (CeCe) 治疗 OAB 的疗效。研究设计 这是一项前瞻性观察试验，利用 Renalis 大学医院（俄亥俄州克利夫兰）开发的数字对话代理来治疗 OAB。患者在 8 周的时间内接受了 CeCe 的访问，并接受了如何进行膀胱训练和骨盆底锻炼的指导，并教授了有关膀胱健康的知识。主要结果是国际失禁-膀胱过度活动症咨询生活质量问卷 (ICIQ-OAB-QoL) 评分从第 1 周到第 8 周有所下降。患者还完成了 36 项简短健康调查和广义健康调查以相同的时间间隔进行焦虑障碍问卷调查，并在第 1、4 和 8 周进行排尿日记。进行功效分析并确定总共需要 30 名患者才能证明使用 CeCe 后症状评分有显着差异（80%）功率和 5% 的 α 误差。结果 二十九名患者完成了所有数据收集。第 1 周和第 8 周之间的 ICIQ-OAB-QoL 评分 (62 [IQR], 49-75) 与 32 [IQR, 24-43] 之间存在显着差异；P < 0.001）。患者还报告治疗前和治疗后的频率有所下降（7 次 [IQR，6-10] 对比 5 次 [IQR，4-7]；P = -0.04）、夜尿次数减少（2 次 [IQR，1-3] 对比 1 次 [IQR，4-7]；P = -0.04） 1-2]；P = 0.03），并急迫性尿失禁（2 [IQR，1-5] vs 0 [IQR，0-3]；P = 0.04）。从第 1 周到第 8 周，酒精消耗量（24 盎司 [IQR，12-36 盎司）减少至 14 盎司（IQR，9-22 盎司]；P = 0.02）。结论 使用数字对话代理可以有效减轻 OAB 患者的症状严重程度并提高生活质量。