In this work, we reported the preparation of a novel type of collagen composite fiber with antibacterial properties by utilizing the hydrodynamic focusing effect of the multichannel microfluidic chip and microfluidic wet spinning technology (MWST). Specifically, tannin (TA)-grafted collagen solution was used as the precursor, ethanol anhydrous was used as the sheath flow, and AgNO₃ solution was used as the spacer flow between the precursor and the sheath flow. The morphologies, structures, and properties of obtained collagen composite fibers were seriously analyzed. These results indicated that TA can not only form strong crosslinking networks of hydrogen bonds with collagen fibrils, but also chelate with Ag⁺, thus resulting in a synergistic enhancement of the mechanical properties, thermal stability, and antibacterial properties of collagen/TA-Ag composite fibers. These collagen composite fibers with excellent mechanical properties and antibacterial properties might have potential applications in the surgical suture field.

在这项工作中，我们报道了利用多通道微流控芯片的流体动力聚焦效应和微流湿纺丝技术（MWST）制备了一种具有抗菌性能的新型胶原复合纤维。具体地，使用单宁(TA)接枝胶原溶液作为前体，使用无水乙醇作为鞘流，并且使用AgNO ₃溶液作为前体和鞘流之间的间隔流。对所得胶原复合纤维的形貌、结构和性能进行了认真分析。这些结果表明，TA不仅可以与胶原原纤维形成强的氢键交联网络，而且可以与Ag ^+螯合，从而协同增强胶原/TA-Ag复合材料的机械性能、热稳定性和抗菌性能纤维。这些具有优异机械性能和抗菌性能的胶原复合纤维可能在手术缝合领域具有潜在的应用前景。