BACKGROUND Gonadotrophin-releasing hormone agonist (GnRHa) downregulates gonadotropin secretion in the pituitary gland. It is used both in ovulation induction protocols and in artificial endometrium preparation. Frozen-thawed embryo transfer to artificially prepared endometrium (FET-APE) is a frequent procedure in vitro fertilization (IVF) which requires GnRHa. It can be used either as a daily low-dose injection or as a single depot injection. It is unclear which of these two regimens is superior for artificial endometrium preparation. METHODS We evaluated the data of 72 patients who had undergone frozen embryo transfer following the 5th day Preimplantation Genetic Test-aneuploidy (PGT-A) between 2018-2021. All embryos were genetically screened, and euploid single embryos were transferred. Group 1 (n: 36) used depot GnRHa, and Group 2 (n: 36) used single daily injections for artificial endometrial preparation. The outcomes for Beta Human Chorionic Gonadotrophin (BHCG) positivity and live birth rates (LBR) was compared. RESULTS The BHCG positivity for Group 1 and Group 2 was 75% and 80.6%, respectively. The LBR for Group 1 and Group 2 were found to be 58.3% and 63.9%, respectively. There was no statistically significant differences between the two groups. CONCLUSIONS In artificial endometrium preparation, depot GnRHa offers cheaper and more convenient alternative to single daily dose injections, particularly in busy clinical settings.

中文翻译：

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使用每日 GnRH 激动剂与长效 GnRH 激动剂进行子宫内膜准备后的活产率。

背景促性腺激素释放激素激动剂（GnRHa）下调垂体中促性腺激素的分泌。它可用于促排卵方案和人工子宫内膜制备。冻融胚胎移植到人工制备的子宫内膜 (FET-APE) 是体外受精 (IVF) 的常见程序，需要 GnRHa。它可以用作每日低剂量注射剂或单次储库注射剂。目前尚不清楚这两种方案中哪一种更适合人工子宫内膜制备。方法 我们评估了 2018 年至 2021 年期间第 5 天植入前基因检测非整倍体 (PGT-A) 后接受冷冻胚胎移植的 72 名患者的数据。所有胚胎均经过基因筛选，并移植整倍体单胚胎。第 1 组 (n: 36) 使用长效 GnRHa，第 2 组 (n: 36) 使用每日一次注射进行人工子宫内膜准备。比较了 β 人绒毛膜促性腺激素 (BHCG) 阳性结果和活产率 (LBR)。结果 第 1 组和第 2 组的 BHCG 阳性率分别为 75% 和 80.6%。第 1 组和第 2 组的 LBR 分别为 58.3% 和 63.9%。两组之间没有统计学上的显着差异。结论 在人工子宫内膜制备中，长效 GnRHa 提供了比每日单剂量注射更便宜、更方便的替代方案，特别是在繁忙的临床环境中。