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Preparation of Mannich reaction modified magnetic adsorbent for separation and purification of total flavonoids from Lycium barbarum leaves
Reactive & Functional Polymers ( IF 5.1 ) Pub Date : 2023-11-24 , DOI: 10.1016/j.reactfunctpolym.2023.105797
Qirui Lou , Dong Pei , Quan Hao , Ningli Wang , Duolong Di , Baoqian Liu

Flavonoids are important secondary metabolites, but their separation and enrichment are difficult due to low contents and complex active components. Poly(styrene-divinylbenzene)-based resins are widely used for the separation of natural products, however, they have low adsorption capacity and poor selectivity. To solve these problems, Mannich reaction modified magnetic poly(styrene-divinylbenzene) (MPM-MR) microspheres were synthesized, and used for the separation and purification of flavonoids from Lycium barbarum leaves. Compared with other flavonoids (such as kaempferol, quercetin, naringenin and rutin), MPM-MR exhibited higher adsorption capacity and better selectivity for myricetin, which reached 81.6 mg/g at 298.15 K. Sieving interactions, hydrogen bonds and π-π interactions mainly exist between the MPM-MR and the flavonoids. In addition, the materials showed good enrichment of total flavonoids from actual samples of Lycium barbarum leaves, which increased from 8.17% to 24.99%. The Mannich reaction-modified magnetic poly(styrene-divinylbenzene) would be a promising material for efficient capture of flavonoids from natural plants.



中文翻译:


曼尼希反应修饰磁性吸附剂的制备用于枸杞叶总黄酮的分离纯化



黄酮类化合物是重要的次生代谢产物,但其含量低、活性成分复杂,分离富集困难。聚苯乙烯-二乙烯基苯树脂广泛用于天然产物的分离,但其吸附容量低、选择性差。针对这些问题,合成了曼尼希反应修饰的磁性聚苯乙烯-二乙烯基苯(MPM-MR)微球,并将其用于枸杞叶中黄酮类化合物的分离纯化。与其他黄酮类化合物(如山奈酚、槲皮素、柚皮素和芦丁)相比,MPM-MR 对杨梅素表现出更高的吸附容量和更好的选择性,在 298.15 K 时达到 81.6 mg/g。筛分相互作用、氢键和 π-π 相互作用主要存在于 MPM-MR 和黄酮类化合物之间。此外,该材料对枸杞叶实际样品中的总黄酮含量也表现出良好的富集作用,从8.17%提高到24.99%。曼尼希反应改性的磁性聚(苯乙烯-二乙烯基苯)将成为有效捕获天然植物中黄酮类化合物的有前途的材料。

更新日期:2023-11-24
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