Louis, Alexandre, Charlotte Pröpper, Yann Savina, Corentin Tanne, Guy Duperrex, Paul Robach, Pascal Zellner, Stéphane Doutreleau, Jean-Michel Boulet, Alain Frey, Fabien Pillard, Cristina Pistea, Mathias Poussel, Thomas Thuet, Jean-Paul Richalet, and François Lecoq-Jammes. The impact of COVID-19 on the response to hypoxia. High Alt Med Biol. 00:000-000, 2023. Introduction: Severe high-altitude illness (SHAI) and coronavirus disease 2019 (COVID-19), while differing in most aspects of pathophysiology, both involve respiratory capacity. We examined the long-term impact of COVID-19 on response to hypoxia in individuals free of symptoms but having tested positive during the pandemic. The need for recommendations for such individuals planning a stay at high altitude are discussed. Methods: This multicenter study recruited participants from the multiSHAI cohort, all of whom had previously undergone a hypoxic exercise test. These participants were classified into two groups depending on whether they had since suffered mild-to-moderate COVID-19 (COVID+) or not (Control) and then asked to retake the test. Primary outcomes were: desaturation induced by hypoxia at exercise (ΔSpE), hypoxic cardiac response at exercise, hypoxic ventilatory response at exercise, and SHAI risk score. Results: A total of 68 participants retook the test, 36 classified in the COVID+ group. Analyses of primary outcomes showed no significant differences between groups. However, the COVID+ group showed significantly increased ventilation (VE) parameters during both hypoxic (p = 0.003) and normoxic exercise (p = 0.007). However, only the VE/oxygen consumption relationship during hypoxic exercise was significantly different. Conclusion: This study demonstrates no negative impact of COVID-19 on response to hypoxia as evaluated by the Richalet test. Clinical Trial Registration: NTC number: NCT05167357.

中文翻译：

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COVID-19 对缺氧反应的影响。

路易斯、亚历山大、夏洛特·普罗珀、扬·萨维纳、科朗坦·坦内、盖伊·杜佩雷克斯、保罗·罗巴赫、帕斯卡·泽尔纳、斯特凡·杜特勒洛、让-米歇尔·鲍莱特、阿兰·弗雷、法比安·皮拉德、克里斯蒂娜·皮斯蒂亚、马蒂亚斯·波塞尔、托马斯·图埃、让-保罗·里查莱特、和弗朗索瓦·勒科克-贾梅斯。COVID-19 对缺氧反应的影响。高替代医学生物。00:000-000, 2023。简介：严重高原病 (SHAI) 和 2019 年冠状病毒病 (COVID-19) 虽然在病理生理学的大多数方面有所不同，但都涉及呼吸能力。我们研究了 COVID-19 对没有症状但在大流行期间检测呈阳性的个体缺氧反应的长期影响。讨论了为这些计划在高海拔地区停留的人提供建议的必要性。方法：这项多中心研究从 multiSHAI 队列中招募了参与者，所有参与者之前都接受过低氧运动测试。根据参与者是否患有轻度至中度 COVID-19 (COVID+)（对照组），将这些参与者分为两组，然后要求重新参加测试。主要结局为：运动时缺氧引起的去饱和度 (ΔSpE)、运动时缺氧心脏反应、运动时缺氧通气反应和 SHAI 风险评分。结果：共有 68 名参与者重新参加了测试，其中 36 人属于新冠肺炎 + 组。主要结局分析显示各组之间没有显着差异。然而，COVID+ 组在低氧运动 (p = 0.003) 和常氧运动 (p = 0.007) 期间通气 (VE) 参数均显着增加。然而，只有低氧运动时的VE/耗氧量关系存在显着差异。结论：本研究表明，根据 Richalet 试验评估，COVID-19 对缺氧反应没有负面影响。临床试验注册：NTC 编号：NCT05167357。