Bilirubin, a severe endogenous toxin, underscores the critical need for the development of bilirubin adsorbents exhibiting both high removal efficiency and exceptional hemocompatibility. Such advancements are pivotal for augmenting the efficacy of hemoperfusion therapy in managing hyperbilirubinemia. Here, a polyacrylonitrile-polyethyleneimine (PAN-PEI) nanofiber membrane (NFM) with elevated amino content was prepared using a facile reflux method for bilirubin adsorption. The PAN-PEI NFMs exhibited a significantly augmented surface amino density of 23.5 mmol.m⁻², consequently achieving a remarkable bilirubin adsorption capacity of 87.65 mg.g⁻¹, along with an impressive removal efficiency of 92.3% for bilirubin. Additionally, these nanofiber membranes displayed excellent hemocompatibility, including minimal hemolysis rates, significant anti-protein and anti-hemocyte adhesion properties, as well as a certain degree of anticoagulant activity. These results indicate that the vast potential of using PAN-PEI nanofiber membranes for hyperbilirubinemia hemoperfusion therapy.

胆红素是一种严重的内源性毒素，强调了开发具有高去除效率和出色的血液相容性的胆红素吸附剂的迫切需要。这些进步对于提高血液灌流疗法治疗高胆红素血症的疗效至关重要。在此，采用简易回流法制备了氨基含量较高的聚丙烯腈-聚乙烯亚胺（PAN-PEI）纳米纤维膜（NFM），用于胆红素吸附。PAN-PEI NFM表现出显着增加的表面氨基密度，达到23.5 mmol.m ^{-2 ，从而实现了87.65 mg.g -1}的显着胆红素吸附能力，以及令人印象深刻的92.3%的胆红素去除效率。此外，这些纳米纤维膜表现出优异的血液相容性，包括最小的溶血率、显着的抗蛋白和抗血细胞粘附特性以及一定程度的抗凝血活性。这些结果表明使用PAN-PEI纳米纤维膜用于高胆红素血症血液灌流治疗的巨大潜力。