Introduction

Chinese herbal medicine is widely used for treating polycystic ovary syndrome (PCOS). The present study aimed to explore the effects of Bu-Shen-Jian-Pi Formula, a Chinese herbal medicine formula, on the pregnancy outcomes of women with PCOS undergoing in vitro fertilization and embryo transfer (IVF-ET) based on a retrospective cohort study.

Methods

One hundred and forty-six females with PCOS undergoing IVF-ET were included in the study from Women's Hospital, School of Medicine, Zhejiang University between July 2016 and June 2021, of whom 73 patients received Bu-Shen-Jian-Pi Formula treatment for 12 weeks before IVF-ET, while the other 73 did not. The clinical data were collected from the medical records of the included patients. Bone morphogenetic protein 15 (BMP15) and leukemia inhibitory factor levels in the follicular fluids were detected.

Results

After the treatment of Bu-Shen-Jian-Pi Formula, women with PCOS undergoing IVF-ET exhibited significant improvement in the fertilization (P<0.05), good-quality embryo (P<0.01), clinical pregnancy (P<0.01), and live birth (P<0.01) rates, and single birthweight in newborns (P<0.05). The expression levels of BMP15 in the follicular fluids of the women with PCOS were significantly increased after Bu-Shen-Jian-Pi Formula treatment (P<0.05).

Conclusion

This study provided preliminary evidence of a significant association of Bu-Shen-Jian-Pi Formula treatment with improved pregnancy outcomes in women with PCOS undergoing IVF-ET, partly through increasing BMP15 levels in the follicular fluids.

中文翻译：

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中草药对 PCOS 女性体外受精和胚胎移植妊娠结局的影响：一项回顾性队列研究

介绍

中草药广泛用于治疗多囊卵巢综合症（PCOS）。本研究旨在基于回顾性队列研究，探讨补肾健脾方（一种中药方剂）对接受体外受精胚胎移植（IVF-ET）的多囊卵巢综合征（ PCOS）女性妊娠结局的影响。 。

方法

该研究纳入2016年7月至2021年6月浙江大学医学院附属妇女医院接受IVF-ET治疗的146名PCOS女性患者，其中73名患者接受补肾健脾方治疗。 IVF-ET 前 12 周，而其他 73 人则没有。临床数据是从纳入患者的医疗记录中收集的。检测卵泡液中骨形态发生蛋白15（BMP15）和白血病抑制因子的水平。

结果

接受补肾健脾方治疗后，接受IVF-ET的PCOS女性受精率（P<0.05）、胚胎质量（P<0.01）、临床妊娠（P<0.01）、妊娠率等指标均显着改善。活产率（P<0.01），以及新生儿单胎出生体重（P<0.05）。补肾健脾方治疗后PCOS女性卵泡液中BMP15表达水平显着升高（P<0.05）。

结论

这项研究提供了初步证据，证明补肾健脾方治疗与接受 IVF-ET 的 PCOS 女性妊娠结局的改善存在显着关联，部分原因是通过增加卵泡液中的 BMP15 水平。