The systemic complications of acute hematologic emergencies account for the high mortality rates seen during inpatient management. Perhaps the most challenging diagnostic entity among all hematologic emergencies is leukostasis. In acute myeloid leukemia, myeloid blasts are often highly adherent to the endothelial vasculature, and high peripheral blood blast count in excess of 100,000 cells per microliter can predispose patients to the pulmonary and neurologic complications, leading to rapid clinical deterioration even before a formal diagnosis of leukostasis is made. The mobilization of the appropriate healthcare personnel in the inpatient setting at inopportune times sometimes poses a major barrier to the successful treatment for patients with leukostasis, and patients often pass away quickly. In this report, we describe clinico-radio-pathologic correlations of leukostasis using pre- and post-mortem analysis in a patient with acute myeloid leukemia (AML) with a FLT3-TKD mutation, and we describe the current literature on best management approaches based on recent evidence.

中文翻译：

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急性髓系白血病白细胞停滞与 FLT3 突变的临床-放射-病理相关性。

急性血液急症的全身并发症是住院治疗期间死亡率较高的原因。也许所有血液急症中最具挑战性的诊断实体是白细胞停滞。在急性髓系白血病中，髓系母细胞通常高度粘附于内皮血管系统，并且外周血母细胞计数超过每微升 100,000 个细胞，可能使患者容易出现肺部和神经系统并发症，甚至在正式诊断为白血病之前就导致临床迅速恶化。白细胞停滞。在不合时宜的情况下在住院环境中动员适当的医护人员有时会对白细胞淤积患者的成功治疗造成重大障碍，并且患者往往很快就会去世。在本报告中，我们通过对患有 FLT3-TKD 突变的急性髓系白血病 (AML) 患者进行死前和死后分析来描述白细胞停滞的临床放射病理学相关性，并描述了基于根据最近的证据。