Objectives

To evaluate the efficacy of pain management of 1 ml of 24% sucrose given orally compared to routine care given one minute before vaccination for reduction of pain.

Methods

This double-blind randomized controlled trial included term neonates visiting Pediatric OPD for immunization. Neonates were randomly assigned into two groups (Group A- Sucrose, Group B- Swaddling). Commercially available sucrose solution (StayHappi solution 24%) was given in a dose of 1 ml to the neonates. Video recording of the neonate’s facial expression was done during the procedure. Duration of cry, latency of onset of cry as well Modified Neonatal Facial Coding Score (MFCS) were the outcome variables.

Results

The mean (SD) of birth weight and gestational age was 2729 (321.6) g and 38.24 (0.84) d, respectively. Analysis showed significant difference in total MFCS across the groups (P <0.001). Total MFCS was significantly lower in sucrose group [4.88 (1.07) vs. 7.17 (0.95)]. The duration of cry (in seconds) was also found to be significantly lower in sucrose group.

Conclusions

Administration of 1 ml 24% sucrose one minute prior to immunization is efficacious in pain management during injectable immunization.

中文翻译：

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蔗糖与襁褓在出生时注射乙型肝炎疫苗期间疼痛管理的比较：随机对照试验

目标

旨在评估口服 1 毫升 24% 蔗糖的疼痛管理效果与疫苗接种前一分钟给予常规护理以减轻疼痛的效果。

方法

这项双盲随机对照试验包括到儿科 OPD 进行免疫接种的足月新生儿。新生儿被随机分为两组（A 组 - 蔗糖，B 组 - 襁褓）。给新生儿服用市售蔗糖溶液（StayHappi溶液24%），剂量为1ml。在手术过程中对新生儿的面部表情进行了视频记录。哭泣持续时间、哭泣开始潜伏期以及改良新生儿面部编码评分（MFCS）是结果变量。

结果

出生体重和胎龄的平均值 (SD) 分别为 2729 (321.6) g 和 38.24 (0.84) 天。分析显示各组的总 MFCS 存在显着差异（P <0.001）。蔗糖组的总 MFCS 显着较低 [4.88 (1.07) vs. 7.17 (0.95)]。还发现蔗糖组的哭泣持续时间（以秒为单位）显着缩短。

结论

免疫前一分钟给予 1 ml 24% 蔗糖对于注射免疫期间的疼痛控制是有效的。