Barrier tissues are highly innervated by sensory and autonomic nerves that are positioned in close proximity to both stromal and immune cell populations. Together with a growing awareness of the far-reaching consequences of neuroimmune interactions, recent studies have uncovered key mechanisms through which they contribute to organ homeostasis and immunity. It has also become clear that dysregulation of such interactions is implicated in the development of chronic lung diseases. This review describes the characteristics of the lung nervous system and discusses the molecular mechanisms that underlie lung neuroimmune interactions in infection and disease. We have contextualized the current literature and identified opportune areas for further investigation. Indeed, both the lung-brain axis and local neuroimmune interactions hold enormous potential for the exploration and development of novel therapeutic strategies targeting lung diseases.Expected final online publication date for the Annual Review of Immunology, Volume 42 is April 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

中文翻译：

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肺部的神经免疫相互作用

屏障组织受到感觉和自主神经的高度支配，这些神经与基质和免疫细胞群非常接近。随着人们越来越认识到神经免疫相互作用的深远影响，最近的研究发现了神经免疫相互作用促进器官稳态和免疫的关键机制。人们还清楚地认识到，这种相互作用的失调与慢性肺病的发展有关。这篇综述描述了肺神经系统的特征，并讨论了感染和疾病中肺神经免疫相互作用的分子机制。我们对当前文献进行了背景分析，并确定了需要进一步研究的合适领域。事实上，肺-脑轴和局部神经免疫相互作用对于探索和开发针对肺部疾病的新型治疗策略具有巨大的潜力。《免疫学年度评论》第 42 卷的预计最终在线出版日期为 2024 年 4 月。请参阅 http: //www.annualreviews.org/page/journal/pubdates 了解修订后的估计。