Background: Dendritic cells (DCs) are the most important antigen-presenting cells in the body and play a key role in antigen recognition, uptake, processing, and presentation and mediate nonspecific immunity and specific immunity. Purpose: To summarize the main findings that DC vaccines are a new immunotherapy scheme combining the strengths of tumor antigens and DCs that can boost the body's identification and clearance of tumors. Methods: In this review, the authors focus on the biological characteristics of DCs, recent advances in the understanding of antitumor mechanisms, and the classification of DC vaccines. Results: The current progress of DC-based vaccine immunotherapy for common tumors with high morbidity or mortality in China were systematically summarize. Conclusions: The DC vaccines combining the strengths of tumor antigens will provide directions to explore reasonable, safe, and effective combination immunotherapy strategies for tumors in the future.

中文翻译：

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抗肿瘤树突状细胞疫苗的最新进展。

背景：树突状细胞（DC）是体内最重要的抗原呈递细胞，在抗原识别、摄取、加工和呈递中发挥关键作用，介导非特异性免疫和特异性免疫。目的：总结DC疫苗是一种新的免疫治疗方案，结合了肿瘤抗原和DC的优势，可以促进人体对肿瘤的识别和清除。方法：在这篇综述中，作者重点讨论了 DC 的生物学特性、抗肿瘤机制的最新进展以及 DC 疫苗的分类。结果：系统总结了我国高发病率或死亡率的常见肿瘤基于DC的疫苗免疫治疗的研究进展。结论：结合肿瘤抗原优势的DC疫苗将为今后探索合理、安全、有效的肿瘤联合免疫治疗策略提供方向。