Lung cancer in never smokers (LCINS) represents a growing and distinct entity within the broader landscape of lung malignancies. This review provides a comprehensive overview of LCINS, encompassing its epidemiologic trends, risk factors, distinct genomic alterations, clinical outcomes and the ongoing initiative aimed at formulating screening guidelines tailored to this unique population. As LCINS continues to gain prominence, understanding its intricate genomic landscape has become pivotal for tailoring effective therapeutic strategies. Moreover, LCINS does not meet the criteria for lung cancer screening as per the current guidelines. Hence, there is an urgent need to explore its heterogeneity in order to devise optimal screening guidelines conducive to early-stage detection. This review underscores the vital importance of detailed research to elucidate the multifaceted nature of LCINS, with the potential to shape future clinical management and screening recommendations for this unique and growing patient cohort.

从不吸烟者肺癌 (LCINS) 代表了更广泛的肺部恶性肿瘤中一个不断增长的独特实体。本综述对 LCINS 进行了全面概述，包括其流行病学趋势、危险因素、独特的基因组改变、临床结果以及旨在制定针对这一独特人群的筛查指南的持续举措。随着 LCINS 不断获得关注，了解其复杂的基因组景观已成为制定有效治疗策略的关键。此外，LCINS 不符合现行指南的肺癌筛查标准。因此，迫切需要探索其异质性，以制定有利于早期检测的最佳筛查指南。本综述强调了详细研究对于阐明 LCINS 的多方面性质的至关重要性，并有可能为这一独特且不断增长的患者群体制定未来的临床管理和筛查建议。