INTRODUCTION The purpose of this study was to examine the effect of iron overload on the mobilization of peripheral blood stem cells (PBSCs) in pediatric patients with ꞵ-thalassemia major (TM). METHODS We retrospectively reviewed the records of 226 patients with TM from whom PBSCs were collected. Iron overload was based on serum ferritin level, and liver and cardiac iron overload measured by magnetic resonance imaging (MRI) T2*. RESULTS The mean age of the TM patients was 7.35 ± 3.41 years. Of the patients, only 171 received MRI. Of the 171 patients, 35 had normal liver iron levels, 39 mild liver iron overload, 90 intermediate liver iron overload, and 7 severe liver iron overload. The intermediate + severe group was associated with significantly higher age and BMI, and lower leukapheresis-product WBC count and and CD34+ cell levels (all, P < 0.05). CONCLUSION Leukapheresis indices were similar between patients with different degrees of iron overload according to the ferritin level and cardiac iron overload , in which the later might be due to the small number of patients with cardiac overload. In patients with TM, the intermediate and severe liver iron overload was associated with poorer mobilization of PBSCs.

中文翻译：

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铁过载对重型地中海贫血儿科患者外周血造血干细胞动员的影响。

简介 本研究的目的是检查铁过载对重型 β 地中海贫血 (TM) 儿科患者外周血干细胞 (PBSC) 动员的影响。方法 我们回顾性审查了 226 名 TM 患者的记录，并从中收集了 PBSC。铁超负荷是基于血清铁蛋白水平，以及通过磁共振成像 (MRI) T2* 测量的肝脏和心脏铁超负荷。结果 TM 患者的平均年龄为 7.35 ± 3.41 岁。在这些患者中，只有 171 人接受了 MRI 检查。171 名患者中，35 名肝铁水平正常，39 名轻度肝铁超负荷，90 名中度肝铁超负荷，7 名重度肝铁超负荷。中度+重度组与显着较高的年龄和BMI以及较低的白细胞分离产物WBC计数和CD34+细胞水平相关（全部，P < 0.05）。结论铁蛋白水平和心脏铁超负荷不同程度铁超负荷患者的白细胞去除指数相似，其中后者可能是由于心脏超负荷患者数量较少所致。在 TM 患者中，中度和重度肝脏铁超负荷与 PBSC 动员较差相关。