OBJECTIVE This paper focuses on the outcomes at one-year post-treatment of a naturalistic evaluation of services provided through the Takiwasi Centre, an accredited Peruvian therapeutic community offering an ayahuasca-assisted, integrative treatment program for addiction rehabilitation. METHODS Participants (n=52) completed structured interviews and a battery of validated instruments. Outcome measures included the Addiction Severity Index (V. 5), the Beck Anxiety and Depression Inventories, the WHOQOL-BREF and the WHOQOL-SRPB. Likert rating scales were used to assess perceived importance and significance of different aspects of the program and overall participant satisfaction. RESULTS The group change from baseline to the one-year follow up was significant and in the anticipated direction for alcohol and drug use severity, depression and anxiety, and some dimensions of quality of life. There was considerable individual variation in outcomes and treatment duration. The majority of participants rated all aspects of the program as important, including the spiritual and therapeutic significance of the ayahuasca experience which was rated as very significant. CONCLUSION Based on the positive one-year outcomes, and within the limitations of an uncontrolled observational study design, the findings suggest promise for the effectiveness of the use of ayahuasca in a multifactorial treatment context for individuals with significant treatment histories, high levels of comorbidity and treatment motivation. Results highlight considerable variation in individual experience that merit in-depth qualitative analysis. Implications for ayahuasca-assisted and other psychedelic-assisted treatment alternatives are discussed.

中文翻译：

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死藤水治疗成果项目 (ATOP)：塔基瓦西中心一年的结果及其对迷幻科学的影响

目的 本文重点关注对 Takiwasi 中心提供的服务进行自然主义评估的一年后的结果，Takiwasi 中心是一个经过认可的秘鲁治疗社区，提供死藤水辅助的成瘾康复综合治疗计划。方法 参与者 (n=52) 完成了结构化访谈和一系列经过验证的工具。结果测量包括成瘾严重程度指数 (V. 5)、贝克焦虑和抑郁量表、WHOQOL-BREF 和 WHOQOL-SRPB。李克特评分量表用于评估项目不同方面的感知重要性和意义以及参与者的总体满意度。结果 从基线到一年随访，该组的变化非常显着，并且在酒精和药物使用严重程度、抑郁和焦虑以及生活质量的某些方面都朝着预期的方向发展。结果和治疗持续时间存在很大的个体差异。大多数参与者认为该计划的各个方面都很重要，其中死藤水体验的精神和治疗意义被认为非常重要。结论 基于积极的一年结果，并且在不受控制的观察性研究设计的限制内，研究结果表明，对于具有显着治疗史、高水平合并症和治疗动机。结果突显了个人经历的巨大差异，值得进行深入的定性分析。讨论了死藤水辅助和其他迷幻辅助治疗替代方案的影响。