Cancer chemotherapy has been shifted from conventional cytotoxic drug therapy to selective and target-specific therapy after the findings about DNA changes and proteins that are responsible for cancer. A large number of newer drugs were discovered as targeted therapy for particular types of neoplastic disease. The initial discovery includes the development of the first in the category, imatinib, a Bcr-Abl tyrosine kinase inhibitor (TKI) for the treatment of chronic myelocytic leukemia in 2001. But the joy did not last for long as the drug developed a point mutation within the ABL1 kinase domain of BCR-ABL1, which subsequently led to the discovery of many other TKIs. Resistance was observed for newer TKIs a few years after their launching, but the use of TKIs in life-threatening cancer therapy is considered as far better compared with the risks of disease because of its target specificity and hence less toxicity. In search of a better anticancer agent, the physiochemical properties of the lead molecule have been modified for its efficacy toward disease and delay in the development of resistance. Deuteration in the drug molecule is one of such modifications that alter the pharmacokinetic properties, generally its metabolism, as compared with its pharmacodynamic effects. Precision deuteration in many anticancer drugs has been carried out to search for better drugs for cancer. In this review, the majority of anticancer drugs and molecules for which deuteration was applied to get better anticancer molecules were discussed. This review will provide a complete guide about the benefits of deuteration in cancer chemotherapy.

中文翻译：

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寻找抗癌药物的精确氘化：癌症药物发现方法。

在发现导致癌症的 DNA 变化和蛋白质后，癌症化疗已从传统的细胞毒性药物治疗转向选择性和靶向特异性治疗。大量新药被发现可用于特定类型肿瘤疾病的靶向治疗。最初的发现包括开发该类别中的第一个伊马替尼，这是一种 Bcr-Abl 酪氨酸激酶抑制剂 (TKI)，于 2001 年用于治疗慢性粒细胞白血病。但喜悦并没有持续多久，因为该药物出现了点突变BCR-ABL1 的 ABL1 激酶结构域内，随后导致了许多其他 TKI 的发现。较新的 TKI 在推出几年后就出现了耐药性，但由于其靶标特异性和较低的毒性，与疾病风险相比，在危及生命的癌症治疗中使用 TKI 被认为要好得多。为了寻找更好的抗癌剂，先导分子的理化特性已被修改，以提高其对疾病的功效并延缓耐药性的发展。药物分子中的氘化是改变药代动力学特性（通常是其代谢与其药效作用相比）的修饰之一。人们对许多抗癌药物进行了精密氘化，以寻找更好的抗癌药物。在这篇综述中，讨论了大多数抗癌药物和应用氘化以获得更好抗癌分子的分子。这篇综述将提供有关癌症化疗中氘化益处的完整指南。