Mallory-Denk bodies (MBD), described in alcoholic hepatitis, are composed of intermediate filaments admixed with other proteins. These cytoplasmic inclusions are irregularly shaped and eosinophilic as seen under the light microscope. MBD-like inclusions have rarely been described outside the hepatobiliary tree. Though rare, intracytoplasmic inclusions have been reported in ovarian fibromas. This study evaluates a series of torsed ovarian fibromas with intracytoplasmic inclusions resembling MDBs. Forty-three ovarian fibromas were retrieved from the pathology archives. The H&E slides were evaluated for the presence of MBD-like inclusions and histologic evidence of torsion. The cases with histologic features of torsion were included in the study group while the nontorsed fibromas formed the control group. Among the 15 cases of fibromas with torsion, MBD-like intracytoplasmic inclusions were seen in 5 cases, predominantly in the interface between necrotic areas and viable stroma. None of the cases from the control group showed any inclusions. There was no significant difference in the size of the fibroma or patient demographics between cases with and without inclusions. The inclusions were positive for cytokeratin and ubiquitin while being negative for per acidic Schiff and periodic acid-Schiff with diastase reaction, in the 3 cases selected for immunohistochemistry and special stains. Electron microscopy of the index case revealed a predominance of type 3 Mallory hyaline. This is the first report describing MDB-like inclusions in ovarian fibromas. These MDB-like inclusions appear to be limited to a fraction of ovarian fibromas that underwent torsion, suggesting that these inclusions likely result from subacute hypoxic damage to the cells.

中文翻译：

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定义卵巢纤维瘤中 Mallory-Denk 样包涵体的性质和临床病理学意义：与扭转相关的潜在退行性现象。

酒精性肝炎中描述的 Mallory-Denk 小体 (MBD) 由与其他蛋白质混合的中间丝组成。在光学显微镜下观察，这些细胞质内含物形状不规则且呈嗜酸性。在肝胆系统之外，很少有类似 MBD 的内含物被描述。尽管罕见，但在卵巢纤维瘤中已有胞浆内包涵体的报道。本研究评估了一系列具有类似于 MDB 的胞质内包涵体的扭转卵巢纤维瘤。从病理档案中检索到 43 个卵巢纤维瘤。评估 H&E 载玻片是否存在 MBD 样内含物和扭转的组织学证据。将具有扭转组织学特征的病例纳入研究组，将非扭转纤维瘤纳入对照组。15例扭转纤维瘤中，5例可见MBD样胞浆内包涵体，主要位于坏死区与存活间质的界面处。对照组的病例均未显示出任何夹杂物。有或没有包涵体的病例之间，纤维瘤的大小或患者的人口统计数据没有显着差异。3例进行免疫组化和特殊染色，包涵体细胞角蛋白和泛素呈阳性，过酸性希夫和高碘酸希夫呈阴性，并伴有淀粉酶反应。索引病例的电子显微镜显示主要为 3 型 Mallory 透明样。这是第一份描述卵巢纤维瘤中 MDB 样包涵体的报告。这些 MDB 样包涵体似乎仅限于经历扭转的卵巢纤维瘤的一部分，表明这些包涵体可能是由细胞亚急性缺氧损伤引起的。