Sertoli-Leydig cell tumors (SLCT) are rare tumors of the ovary with a peak incidence in the second to third decade of life. Serous borderline tumors (SBT) are epithelial ovarian neoplasms which occur at a median age of 50 years. A co-occurrence of SLCT and SBT has not yet been reported. Here, we describe a case of a 16-year-old girl who presented with irregular menses, virilization, and an abdominopelvic mass. The mass was surgically removed and an intraoperative consultation revealed an 18.5 cm solid and cystic ovarian mass with the presence of co-existing SLCT and SBT. The diagnosis was confirmed on permanent sections after extensive sampling and immunohistochemical stains. The SLCT showed positive staining for calretinin, inhibin, CD99, and androgen receptor. MART-1 immunostain highlighted the Leydig cells. The SBT showed classic features including hierarchically branching papillae lined by stratified serous epithelium. This pediatric case is the first reported case of a Sertoli-Leydig cell tumor arising in association with a serous borderline tumor.

中文翻译：

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一名 16 岁女孩患有中分化卵巢支持间质细胞肿瘤，并发浆液性交界性肿瘤。

支持间质细胞瘤 (SLCT) 是罕见的卵巢肿瘤，发病率高峰在二十至三十岁。浆液性交界性肿瘤 (SBT) 是上皮性卵巢肿瘤，中位年龄为 50 岁。SLCT 和 SBT 同时发生的情况尚未有报道。在这里，我们描述了一名 16 岁女孩的病例，她表现为月经不调、男性化和腹部盆腔肿块。通过手术切除肿块，术中会诊发现一个 18.5 厘米的实性囊性卵巢肿块，同时存在 SLCT 和 SBT。经过大量取样和免疫组织化学染色后，在永久切片上证实了诊断。SLCT 显示钙视网膜蛋白、抑制素、CD99 和雄激素受体染色呈阳性。MART-1 免疫染色突出显示了 Leydig 细胞。SBT 显示出经典特征，包括排列有分层浆液上皮的分层分支乳头。该儿科病例是首例报道的与浆液性交界性肿瘤相关的支持间质细胞瘤病例。