Li Li, Lin Lin, Bo Wen, Peng-cheng Zhao, Da-sheng Liu, Guo-ming Pang, Zi-rong Wang, Yong Tan, and Cheng Lu. Promising natural medicines for the treatment of high-altitude illness. High Alt Med Biol. 24:175-185, 2023.-High-altitude illness (HAI) is a dangerous disease characterized by oxidative stress, inflammatory damage and hemodynamic changes in the body that can lead to severe damage to the lungs, heart, and brain. Natural medicines are widely known for their multiple active ingredients and pharmacological effects, which may be important in the treatment of HAI. In this review, we outline the specific types of HAI and the underlying pathological mechanisms and summarize the currently documented natural medicines applied in the treatment of acute mountain sickness and high-altitude cerebral edema, high-altitude pulmonary edema, chronic mountain sickness, and high-altitude pulmonary hypertension. Their sources, types, and medicinal sites are summarized, and their active ingredients, pharmacological effects, related mechanisms, and potential toxicity are discussed. In conclusion, natural medicines, as an acceptable complementary and alternative strategy with fewer side effects and more long-term application, can provide a reference for developing more natural antialtitude sickness medicines in the future and have good application prospects in HAI treatment.

中文翻译：

---

有前景的天然药物治疗高原疾病。

李莉、林林、文博、赵鹏程、刘大胜、庞国民、王子荣、谭勇和陆成。有望用于治疗高原疾病的天然药物。高替代医学生物。24:175-185, 2023.-高原病 (HAI) 是一种危险的疾病，其特征是体内氧化应激、炎症损伤和血流动力学变化，可导致肺部、心脏和大脑严重受损。天然药物因其多种活性成分和药理作用而广为人知，这对于 HAI 的治疗可能很重要。在这篇综述中，我们概述了HAI的具体类型及其潜在的病理机制，并总结了目前记录的用于治疗急性高山病和高原脑水肿、高原肺水肿、慢性高山病和高原病的天然药物。 - 高原肺动脉高压。总结了它们的来源、类型和药用部位，并讨论了它们的活性成分、药理作用、相关机制和潜在毒性。综上所述，天然药物作为一种副作用较小、应用更长久、可接受的补充和替代策略，可以为未来开发更多的天然抗高原反应药物提供参考，在HAI治疗中具有良好的应用前景。