The proper functioning of cytotoxic lymphocytes, such as natural killer and CD8+ T cells, is essential for effective cancer-immunity and immunotherapy responses. The differentiation of these cells is controlled by several transcription factors (TFs), including members of the activator protein (AP)-1 family. The activity of AP-1 family members is regulated by various immune signaling pathways, which can be triggered by activating or inhibitory receptors as well as cytokines. The target genes controlled by AP-1 TFs are central to generate immunity to pathogens or malignancies. Here, we provide an overview of the current understanding of how AP-1 TFs regulate cytotoxic lymphocytes.

细胞毒性淋巴细胞（例如自然杀伤细胞和 CD8+ T 细胞）的正常功能对于有效的癌症免疫和免疫治疗反应至关重要。这些细胞的分化由多种转录因子 (TF) 控制，包括激活蛋白 (AP)-1 家族的成员。AP-1家族成员的活性受到多种免疫信号通路的调节，这些信号通路可以通过激活或抑制受体以及细胞因子来触发。AP-1 转录因子控制的靶基因对于产生对病原体或恶性肿瘤的免疫力至关重要。在这里，我们概述了目前对 AP-1 TF 如何调节细胞毒性淋巴细胞的理解。