The kidneys are life-sustaining organs that are vital to removing waste from our body. Because of their anatomic position and high blood flow, the kidneys are vulnerable to damage due to infections and autoinflammatory conditions. Even now, our knowledge of immune responses in the kidney is surprisingly rudimentary. Studying kidney-specific immune events are challenging because of the poor regenerative capacity of the nephrons, accumulation of uremic toxins, and hypoxia- and arterial blood pressure–mediated changes, all of which have unexpected positive or negative impacts on the immune response in the kidney. Kidney-specific defense confers protection against pathogens. On the other hand, unresolved inflammation leads to kidney damage and fibrosis. Interleukin-17 is a proinflammatory cytokine that has been linked to immunity against pathogens and pathogenesis of autoinflammatory diseases. In this review, we discuss current knowledge of IL-17 activities in the kidney in the context of infections, autoinflammatory diseases, and renal fibrosis.Expected final online publication date for the Annual Review of Immunology, Volume 42 is April 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

中文翻译：

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感染和损伤期间肾脏特异性白细胞介素 17 反应

肾脏是维持生命的器官，对于清除体内废物至关重要。由于其解剖位置和高血流量，肾脏很容易因感染和自身炎症而受到损害。即使是现在，我们对肾脏免疫反应的了解仍然非常初级。研究肾脏特异性免疫事件具有挑战性，因为肾单位再生能力差、尿毒症毒素积累以及缺氧和动脉血压介导的变化，所有这些都会对肾脏的免疫反应产生意想不到的积极或消极影响。肾脏特异性防御​​可提供针对病原体的保护。另一方面，未解决的炎症会导致肾脏损伤和纤维化。 Interleukin-17 是一种促炎细胞因子，与病原体免疫和自身炎症性疾病的发病机制有关。在这篇综述中，我们讨论了感染、自身炎症性疾病和肾纤维化背景下肾脏中 IL-17 活性的最新知识。《免疫学年度综述》第 42 卷的预计最终在线发布日期为 2024 年 4 月。请参阅 http ://www.annualreviews.org/page/journal/pubdates 了解修订后的估计。