Maternal diabetes can influence the development of offspring during fetal life and postnatally. Curatella americana is a plant used as a menstrual cycle regulator and to prevent diabetes. This study evaluates the effects of C. americana aqueous extract on the estrous cycle and preimplantation embryos of adult female pups from diabetic rats. Female Sprague Dawley newborn rats received Streptozotocin or vehicle (citrate buffer). At adulthood, were submitted to the Oral Glucose Tolerance Test, and mated. The female rats were obtained and were distributed into four experimental groups: OC and OC/T represent female pups of control mothers and received water or plant extract, respectively; OD and OD/T represent female pups of diabetic mothers and received water or plant extract, respectively. The estrous cycle was followed for 10 days, the rats were mated and on gestational day 4 was performed preimplantation embryo analysis. Phenolic composition and biogenic amines in the extract were analyzed about the influence of the thermal process. The female pups from diabetic dams exhibited glucose intolerance, irregular estral cycle and a higher percentage of pre-embryos in delayed development (morula stage). After C. americana treatment, OD/T group no present a regular estrous cycle. Furthermore, the infusion process increases phenolic compounds and biogenic amines levels, which can have anti-estrogenic effect, anticipates the early embryonic development, and impair pre-implantation embryos. Thus, the indiscriminate use of medicinal plants should be avoided in any life phases by women, especially during pregnancy.

母亲糖尿病会影响胎儿期和产后后代的发育。Curatella americana是一种用作月经周期调节剂和预防糖尿病的植物。本研究评估了美洲果水提取物对糖尿病大鼠成年雌性幼崽动情周期和植入前胚胎的影响。雌性 Sprague Dawley 新生大鼠接受链脲佐菌素或载体（柠檬酸盐缓冲液）。成年后，进行口服葡萄糖耐量测试并交配。获得雌性大鼠并分为四个实验组：OC和OC/T代表对照母亲的雌性幼崽，分别接受水或植物提取物；OD 和 OD/T 分别代表糖尿病母亲并接受水或植物提取物的雌性幼崽。动情周期跟踪 10 天，将大鼠交配并在妊娠第 4 天进行植入前胚胎分析。分析了提取物中的酚类成分和生物胺，了解热处理过程的影响。患有糖尿病的母鼠的雌性幼崽表现出葡萄糖不耐受、动情周期不规则以及较高比例的前胚胎发育延迟（桑葚胚阶段）。美洲锦鲤治疗后，OD/T组未出现规律的动情周期。此外，输注过程会增加酚类化合物和生物胺的水平，从而具有抗雌激素作用，预测早期胚胎发育，并损害植入前胚胎。因此，女性在任何生命阶段都应避免滥用药用植物，尤其是在怀孕期间。