An improved, greener, column chromatography free and cost effective process for the preparation of ticagrelor in short route with an overall yield of 70% and 99.7% purity is reported. The process is substantially free from impurities such as hydroxy ticagrelor and amino ticagrelor, etc. In addition to this, the present process is highly robust in controlling all impurity percentages to be within the desired quality of ticagrelor.

中文翻译：

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一种简洁、更环保、改进的可扩展工艺，用于制备抗血栓药物替格瑞洛

据报道，一种改进的、更环保的、无需柱色谱法且具有成本效益的短途制备替格瑞洛的方法，总产率为 70%，纯度为 99.7%。该方法基本上不含诸如羟基替格瑞洛和氨基替格瑞洛等杂质。除此之外，本方法在将所有杂质百分比控制在替格瑞洛的期望质量内方面非常稳健。