An intermolecular enantioselective N-alkylation reaction of 1H-indoles has been developed enabled by cooperative rhodium and chiral phosphoric acid catalyzed N−H bond insertion reaction. The reaction provides the N-alkyl indoles with a newly formed stereocenter adjacent to the indole nitrogen atom in good yields (up to 95 %) with excellent enantioselectivities (up to >99 % ee).

中文翻译：

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通过卡宾插入反应进行 1H-吲哚的不对称 N-烷基化

通过铑和手性磷酸协同催化的N −H键插入反应，开发了1 H -吲哚的分子间对映选择性 N - 烷基化反应。该反应以良好的收率（高达 95%）和优异的对映选择性（高达 >99% ee）提供了具有与吲哚氮原子相邻的新形成的立构中心的 N-烷基吲哚。