Natural killer cells (NK cells) are a type of cytotoxic lymphocytes which are involved in innate immunity, alongside with assisting with adaptive immune response. Since they have cytotoxic effects, disruptions in their functionality and development leads to a variety of conditions, whether malignant or non-malignant. The profile and interaction of these non-coding RNAs and NK cells in different conditions is extensively studied, and it is now approved that if dysregulated, non-coding RNAs have detrimental effects on NK cell activity and can contribute to the pathogenesis of diverse disorders. In this review, we aim at a thorough inspection on the role of different non-coding RNAs on the activity and development of NK cells, in a broad spectrum of conditions, including blood-related disorders, viral infections, neurological diseases, gastrointestinal disorders, lung disorders, reproductive system conditions and other types of maladies, alongside with providing insight to the future non-coding RNA-NK cell studies.

自然杀伤细胞（NK 细胞）是一种细胞毒性淋巴细胞，参与先天免疫，并协助适应性免疫反应。由于它们具有细胞毒性作用，其功能和发育的破坏会导致多种病症，无论是恶性还是非恶性。这些非编码 RNA 和 NK 细胞在不同条件下的概况和相互作用得到了广泛研究，现在已经证实，如果失调，非编码 RNA 会对 NK 细胞活性产生有害影响，并可能导致多种疾病的发病机制。在这篇综述中，我们的目标是在广泛的疾病中，包括血液相关疾病、病毒感染、神经系统疾病、胃肠道疾病、肺部疾病、生殖系统疾病和其他类型的疾病，同时为未来的非编码 RNA-NK 细胞研究提供见解。