The asymmetric synthesis of the key pyrrolidinone core, including a highly elaborated exocyclic carbon chain, of the γ-lactam β-lactone antibiotic oxazolomycin A is described. Principal features include the Birch reduction of an aromatic pyrrole nucleus, a late stage RuO₄ catalyzed pyrrolidine oxidation, and a highly diastereoselective organocerium addition to an aldehyde.

中文翻译：

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恶唑霉素A的全合成吡咯烷酮核心的不对称合成

描述了γ-内酰胺β-内酯抗生素恶唑霉素A的关键吡咯烷酮核心（包括高度复杂的环外碳链）的不对称合成。主要特征包括芳香族吡咯核的桦木还原，后期RuO ₄催化的吡咯烷氧化以及对醛的高度非对映选择性有机铈。