By reacting 2-benzyl-4-hydrazinopyrimidines with ethoxymethylidene derivatives of β-dicarbonyl compounds, the corresponding substituted 4-(1H-pyrazol-1-yl)pyrimidines were synthesized. In a number of examples, intermediates - products of condensation of the reagents in ethanol, were isolated, indicating that the initial attack on the nitrogen atom of the hydrazine fragment involves the ethoxymethylidene group. It was noted that subsequent cyclization of the intermediates in acetic acid leads to 4-(1H-pyrazol-1-yl)pyrimidines. Alkylation of the synthesized non-fused bicyclic systems was carried out and it was proved that the nitrogen atom N-1 of the pyrimidine ring undergoes alkylation. A complex of 2-benzyl-4-(5′-methyl-4′-ethoxycarbonylpyrazol-1′-yl)-6-methylpyrimidine with copper (II) chloride was synthesized. X-ray diffraction analysis proved that, in contrast to the metal complexes of similar pyrazolylpyrimidines, in this case, a single-dentate complex with a linear structure of the composition ligand:metal, 2/1, is formed, and the nitrogen atom N-1 of the pyrimidine ring participates in the formation of a bond with the metal atom, as well as during alkylation. It was found that H/D exchange occurs in pyrazolylpyrimidine molecules in a solution of CD₃ONa in CD₃OD. Using the methods of ¹H NMR spectroscopy and high-resolution mass spectrometry, it was proved that the hydrogen atoms of the alkyl groups of the studied systems undergo isotope exchange. The kinetics of H/D exchange was studied using some examples. It has been shown that the presence of an allyl group in the pyrimidine ring significantly affects the direction and rate of the H/D exchange. The structure of all synthesized substances was confirmed by NMR methods (¹H, ¹³C, NOESY), հigh-resolution mass spectrometry and in some examples X-ray diffraction analysis was also performed.

通过2-苄基-4-肼基嘧啶与β-二羰基化合物的乙氧基亚甲基衍生物反应，合成了相应的取代4-(1H-吡唑-1-基)嘧啶。在许多实例中，分离出中间体——试剂在乙醇中缩合的产物，表明对肼片段的氮原子的最初攻击涉及乙氧基亚甲基。注意到随后中间体在乙酸中的环化产生 4-(1 H-吡唑-1-基)嘧啶。对合成的非稠合双环体系进行烷基化，证明嘧啶环的氮原子N-1发生烷基化。合成了2-苄基-4-(5'-甲基-4'-乙氧基羰基吡唑-1'-基)-6-甲基嘧啶与氯化铜(II)的络合物。X射线衍射分析证明，与类似吡唑基嘧啶的金属配合物相比，在这种情况下，形成了具有配体：金属2/1的线性结构的单齿配合物，并且氮原子N嘧啶环的-1参与与金属原子成键以及烷基化过程。发现CD ₃ ONa溶液中的吡唑基嘧啶分子发生H/D交换_。外径。^利用1 H NMR谱和高分辨率质谱的方法，证明了所研究的体系中烷基的氢原子发生了同位素交换。使用一些例子研究了 H/D 交换的动力学。已经表明，嘧啶环中烯丙基的存在显着影响H/D交换的方向和速率。^{所有合成物质的结构均通过NMR方法( 1} H、¹³ C、NOESY)、高分辨率质谱法确认，并且在一些实施例中还进行X射线衍射分析。