Objective This case series retrospectively reviewed the outcomes in patients implanted with combined, synchronous dorsal root ganglion stimulation (DRGS) and spinal cord stimulation (SCS) connected to a single implantable pulse generator (IPG) in a tertiary referral neuromodulation centre in the United Kingdom. Materials and Methods Twenty-six patients underwent a trial of DRGS+SCS for treating focal neuropathic pain between January 2016 and December 2019, with a follow-up in February 2022. A Transgrade approach was employed for DRGS. Patients were provided with three possible stimulation programmes: DRGS-only, SCS-only, or DRGS+SCS. Patients were assessed for pain intensity, patients’ global impression of change (PGIC), preferred lead(s) and complications. Results Twenty patients were successful and went on for full implantation. The most common diagnosis was Complex Regional Pain Syndrome. After an average of 3.1 years follow-up, one patient was lost to follow-up, and two were non-responders. Of the remaining 17 patients, 16 (94%) continued to report a PGIC of 7. The average pain intensity at Baseline was 8.5 on an NRS scale of 0-10. At the last follow-up, the average NRS reduction overall was 78.9% with no statistical difference between those preferring DRGS+SCS (n = 9), SCS-only (n = 3) and DRGS-only (n = 5). The combination of DRGS+SCS was preferred by 53% at the last follow-up. There were no serious neurological complications. Conclusion This retrospective case series demonstrates the potential effectiveness of combined DRGS+SCS with sustained analgesia observed at an average follow-up of over three years. Implanting combined DRGS+SCS may provide programming flexibility and therapeutic alternatives.

中文翻译：

---

背根神经节和脊髓联合刺激的有效性：慢性局灶性神经病理性疼痛的回顾性单中心病例系列 联合刺激的有效性

目的 本病例系列回顾性回顾了在英国三级转诊神经调节中心植入与单个植入式脉冲发生器 (IPG) 连接的同步背根神经节刺激 (DRGS) 和脊髓刺激 (SCS) 组合的患者的结果。材料和方法 2016 年 1 月至 2019 年 12 月期间，26 名患者接受了 DRGS+SCS 治疗局灶性神经病理性疼痛的试验，并于 2022 年 2 月进行了随访。DRGS 采用 Transgrade 方法。为患者提供了三种可能的刺激方案：仅 DRGS、仅 SCS 或 DRGS+SCS。对患者的疼痛强度、患者总体印象变化（PGIC）、首选导线和并发症进行评估。结果 20 名患者成功并继续完全植入。最常见的诊断是复杂区域疼痛综合症。经过平均 3.1 年的随访，一名患者失访，两名患者无反应。其余 17 名患者中，16 名 (94%) 继续报告 PGIC 为 7。基线时的平均疼痛强度为 8.5（NRS 等级为 0-10）。在最后一次随访中，总体 NRS 平均降低率为 78.9%，偏好 DRGS+SCS (n = 9)、仅 SCS (n = 3) 和仅 DRGS (n = 5) 的患者之间没有统计差异。在最后一次随访中，53% 的人首选 DRGS+SCS 组合。没有出现严重的神经系统并发症。结论 该回顾性病例系列证明了 DRGS+SCS 联合持续镇痛的潜在有效性，平均随访时间超过三年。植入 DRGS+SCS 组合可以提供编程灵活性和治疗替代方案。