Introduction

Hemoglobin A1c (HbA1c) is used to monitor glucose homeostasis and to identify risk for diabetes. As diabetic patients are frequently present with dyslipidaemia, low-grade inflammation and hyperuricemia, we tested whether HbA1c levels can be estimated having the information about lipid profile, uric acid (UA) and C-reactive protein (CRP) levels. We developed formulas to describe the association of these parameters with HbA1c levels.

Methods

Data of 9599 male and 10,817 female patients, measured between 2008 and 2018, were analysed. Patients represented a general hospital patient population with overrepresentation of those with elevated HbA1c over 5.6%. The impact of gender, age, CRP, lipid profile and UA levels on HbA1c % on HbA1c levels was tested with multiple linear regression model. The magnitude of effects of individual factors was used to develop formulas to describe the association between HbA1c and other cardiometabolic parameters. With these formulas we estimated median HbA1c values in each age in both gender and compared them to measured HbA1c levels.

Results

The developed formulas are as follow: HbA1c (estimated) in women = 0.752 + 0.237*log10(HDL/cholesterol) + 0.156*log10 (cholesterol) + 0.077*log10 (triglyceride) + 0.025*log10(CRP) +0.001*log10 (age) −0.026*log10(HDL/LDL) −0.063*log10 (uric acid)-0.075*log10 (LDL)-0.199*log10(HDL); HbA1c (estimated) in men = 1.146 + 0.08*log10 (triglyceride) + 0.046*log10(CRP) + 0.01*log10 (cholesterol) + 0.001*log10 (age) −0.014*log10(HDL)-0.018*log10(HDL/LDL)-0.025*log10(HDL/cholesterol) −0.068*log10 (LDL)-0.159*log10 (uric acid)

Between 20 and 70 years of age, estimated HbA1c matched perfectly to measured HbA1c in.

Conclusion

At population level, HbA1c levels can be estimated almost exactly based on lipid profile, CRP and uric acid levels in female patients between 20 and 70 years.

中文翻译：

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大型医院数据库中血红蛋白 A1c 水平血脂、尿酸、C 反应蛋白水平与年龄的相互关系

介绍

A1c 血红蛋白 (HbA1c) 用于监测葡萄糖稳态并识别糖尿病风险。由于糖尿病患者经常出现血脂异常、低度炎症和高尿酸血症，我们测试了是否可以利用血脂、尿酸 (UA) 和 C 反应蛋白 (CRP) 水平的信息来估计 HbA1c 水平。我们开发了公式来描述这些参数与 HbA1c 水平的关联。

方法

对 2008 年至 2018 年间测量的 9599 名男性和 10,817 名女性患者的数据进行了分析。患者代表了综合医院患者群体，其中 HbA1c 升高超过 5.6% 的患者比例过高。使用多元线性回归模型测试了性别、年龄、CRP、血脂谱和 UA 水平对 HbA1c % 对 HbA1c 水平的影响。各个因素的影响大小被用来开发公式来描述 HbA1c 与其他心脏代谢参数之间的关联。通过这些公式，我们估计了男女各年龄段的 HbA1c 中值，并将其与测量的 HbA1c 水平进行比较。

结果

制定的公式如下： 女性 HbA1c（估计） = 0.752 + 0.237*log10(HDL/胆固醇) + 0.156*log10 (胆固醇) + 0.077*log10 (甘油三酯) + 0.025*log10(CRP) +0.001*log10 (年龄）−0.026*log10（HDL/LDL）−0.063*log10（尿酸）-0.075*log10（LDL）-0.199*log10（HDL）；男性 HbA1c（估计值）= 1.146 + 0.08*log10（甘油三酯）+ 0.046*log10（CRP）+ 0.01*log10（胆固醇）+ 0.001*log10（年龄）−0.014*log10(HDL)-0.018*log10(HDL/ LDL)-0.025*log10(HDL/胆固醇) -0.068*log10 (LDL)-0.159*log10(尿酸)

在 20 岁至 70 岁之间，估计的 HbA1c 与测量的 HbA1c 完全匹配。

结论

在人群水平上，HbA1c 水平几乎可以根据 20 至 70 岁女性患者的血脂、CRP 和尿酸水平来准确估计。