Removal of polyploid cells is essential to preventing cancer and restricting tumor growth. A new study published in The EMBO Journal shows assembly of the NEMO-PIDDosome on extra centrioles. Activation of this protein complex leads to NF-κB activation that, in turn, induces NK cell-mediated cell clearance.

中文翻译：

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有PIDD1吗？自然杀伤细胞清除多倍体细胞以确保基因组平衡

去除多倍体细胞对于预防癌症和限制肿瘤生长至关重要。发表在《EMBO 杂志》上的一项新研究表明 NEMO-PIDDosome 在额外的中心粒上组装。该蛋白复合物的激活会导致 NF-κB 激活，进而诱导 NK 细胞介导的细胞清除。