Coptosapelta flavescens Korth. is one of the medicinal plants used as a traditional medicine in Vietnam for a long time. However, few documents proved its safety for a long time. Therefore, the study aimed to determine the toxicity effects of the aqueous extract of C. flavescens by determining its effects after subchronic oral administration in Swiss albino mice. The toxicity of C. flavescens extract was tested at doses of 400 and 1200 mg/kg, respectively, over 30 and 60 days on an in vivo model. Animal weight, behavior, and condition changes were monitored throughout the process. At the end of the observation periods, hematological indices and histopathological features of the animal specimens were analyzed. The administration of C. flavescens extract at doses of 400 and 1200 mg/kg caused a weight difference in male mice after 30 days and in both sexes after 60 days of administration compared to the control group. There were no significant changes in hematological parameters and biochemical indexes of the liver and kidney compared with the control group. The histological structure of the liver showed changes when treated with C. flavescens at both doses after 60 days, whereas the histological structure of the kidneys exhibited differences only at the dose of 400 mg/kg. Overall, the findings of this study indicate that Coptosapelta flavescens Korth. is unlikely to have subacute and subchronic oral toxicity. However, there are some minor effects on the liver and kidneys.

Coptosapelta flavescens Korth。是越南长期以来用作传统药物的药用植物之一。但长期以来，很少有文献证明其安全性。因此，本研究旨在通过测定苦参水提取物对瑞士白化小鼠亚慢性口服给药后的影响来确定苦参水提取物的毒性作用。分别在 400 和 1200 mg/kg 的剂量下，在 30 和 60 天的体内测试了苦参提取物的毒性。模型。在整个过程中监测动物体重、行为和状况变化。观察期结束时，分析动物标本的血液学指标和组织病理学特征。与对照组相比，以 400 和 1200 mg/kg 剂量施用苦参提取物会导致雄性小鼠在 30 天后以及雌雄小鼠在施用 60 天后出现体重差异。与对照组相比，血液学参数、肝肾生化指标无明显变化。苦参处理后肝脏的组织学结构发生变化60 天后，两种剂量下的肾脏组织学结构仅在 400 mg/kg 剂量下表现出差异。总体而言，本研究的结果表明Coptosapelta flavescens Korth。不太可能有亚急性和亚慢性口服毒性。然而，对肝脏和肾脏有一些轻微影响。