Fungal pathogens have been under the spotlight as their expanding geographic range combined with their potential harm to vulnerable populations turns them into increasingly threats to public health. Therefore, it is ultimately important to unveil the mechanisms associated with their infection process for further new treatment discovery. With this purpose, sphingolipid-based research has gained attention over the last years as these molecules have key properties that can regulate fungal pathogenicity. Here we discuss some of these properties as well as their role in fungal diseases, focusing on the subgroup of glycosphingolipids, as they represent promising molecules for drug discovery and for the development of fungal vaccines.

真菌病原体一直受到人们的关注，因为它们不断扩大的地理范围加上对弱势群体的潜在危害，使它们对公共健康构成越来越大的威胁。因此，最终重要的是揭示与其感染过程相关的机制，以进一步发现新的治疗方法。为此，基于鞘脂的研究在过去几年中引起了人们的关注，因为这些分子具有调节真菌致病性的关键特性。在这里，我们讨论其中一些特性及其在真菌疾病中的作用，重点关注鞘糖脂亚组，因为它们代表了药物发现和真菌疫苗开发的有前途的分子。