Background The evidence shows that risk-based strategy could be implemented to avoid unnecessary harm in mammography screening for breast cancer (BC) using age-only criterium. Our study aimed at identifying the uptake of Slovenian women to the BC risk assessment invitation and assessing the number of screening mammographies in case of risk-based screening. Patients and methods A cross-sectional population-based study enrolled 11,898 women at the age of 50, invited to BC screening. The data on BC risk factors, including breast density from the first 3,491 study responders was collected and BC risk was assessed using the Tyrer-Cuzick algorithm (version 8) to classify women into risk groups (low, population, moderately increased, and high risk group). The number of screening mammographies according to risk stratification was simulated. Results 57% (6,785) of women returned BC risk questionnaires. When stratifying 3,491 women into risk groups, 34.0% were assessed with low, 62.2% with population, 3.4% with moderately increased, and 0.4% with high 10-year BC risk. In the case of potential personalised screening, the number of screening mammographies would drop by 38.6% compared to the current screening policy. Conclusions The study uptake showed the feasibility of risk assessment when inviting women to regular BC screening. 3.8% of Slovenian women were recognised with higher than population 10-year BC risk. According to Slovenian BC guidelines they may be screened more often. Overall, personalised screening would decrease the number of screening mammographies in Slovenia. This information is to be considered when planning the pilot and assessing the feasibility of implementing population risk-based screening.

中文翻译：

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对 3,491 名 50 岁斯洛文尼亚女性进行乳腺癌风险评估和风险分布；基于人群的横断面研究

背景证据表明，可以实施基于风险的策略，以避免使用仅年龄标准进行乳腺癌 (BC) 乳房 X 光检查筛查中不必要的伤害。我们的研究旨在确定斯洛文尼亚女性接受 BC 风险评估邀请的情况，并评估基于风险的筛查情况下进行乳房 X 光检查的数量。患者和方法 一项基于人群的横断面研究招募了 11,898 名 50 岁女性，并受邀参加 BC 筛查。收集了 BC 风险因素的数据，包括前 3,491 名研究响应者的乳腺密度，并使用 Tyrer-Cuzick 算法（第 8 版）评估 BC 风险，将女性分为风险组（低风险、人群、中度增加和高风险）团体）。模拟了根据风险分层进行乳房X线检查的筛查次数。结果 57% (6,785) 的女性返回了 BC 风险问卷。将 3,491 名女性分为危险组时，34.0% 的女性 10 年 BC 风险评估为低风险，62.2% 为人群评估，3.4% 为中度风险评估，0.4% 为高风险评估。在潜在的个性化筛查的情况下，与目前的筛查政策相比，乳房X光检查的筛查数量将下降38.6%。结论 研究表明邀请女性定期进行 BC 筛查时进行风险评估的可行性。3.8% 的斯洛文尼亚女性被认为具有高于人口的 10 年 BC 风险。根据斯洛文尼亚不列颠哥伦比亚省的指导方针，他们可能会更频繁地接受筛查。总体而言，个性化筛查将减少斯洛文尼亚乳房X光检查的筛查数量。在规划试点和评估实施基于人群风险的筛查的可行性时，应考虑这些信息。