Three-dimensional (3D) microscopy and image data analysis are necessary for studying the morphology of cardiac lymphatic vessels (LyVs) and their association with other cell types. We aimed to develop a methodology for 3D multiplexed lightsheet microscopy and highly sensitive and quantitative image analysis to identify pathological remodeling in the 3D morphology of LyVs in young adult mouse hearts with familial hypertrophic cardiomyopathy (HCM).

中文翻译：

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小鼠心脏心脏淋巴管的三维空间定量分析

三维 (3D) 显微镜和图像数据分析对于研究心脏淋巴管 (LyV) 的形态及其与其他细胞类型的关联是必要的。我们的目标是开发一种 3D 多重光片显微镜和高灵敏度定量图像分析方法，以识别患有家族性肥厚型心肌病 (HCM) 的年轻成年小鼠心脏中 LyV 3D 形态的病理重塑。