Two new 30-norfriedelane triterpenoids namely glaucalactone C (1) and glaucanoic acid (2) along with sixteen known compounds (3–18) have been isolated from the methanolic extracts of the stem bark and fruits of Caloncoba glauca (P.Beauv.) Gilg (Achariaceae). The structures of all the isolated compounds have been established with the aid of their extensive spectroscopic analyses (1D and 2D-NMR) as well as mass spectrometry. Six compounds (1–5, 9) were screened for antiplasmodial activity against two strains P. falciparum Dd2 and P. falciparum 3D7. The results showed that glaucanoic acid (2) was the most active one with IC₅₀ values of (3.5 ± 0.1 μg/mL) and (4.6 ± 0.7 μg/mL) against PfDd2 and Pf3D7, respectively, while glaucalactone C (1) moderately inhibited PfDd2 (9.4 ± 0.1 μg/mL) and weakly Pf3D7 (15.9 ± 2.3 μg/mL). The molecular docking analyses of the isolated compounds showed that compounds 1–4 and 9–11 are potential drug targets and were further supported by their ADMET studies that revealed welwitschiilactones B and C (4 and 5) as well as β-sitosterol (10) as the most qualified compounds to be safe as drugs. The results indicate that C. glauca is an important source of good candidates in new antiplasmodial drug development.

从Caloncoba glauca (P.Beauv.)的茎皮和果实的甲醇提取物中分离出两种新的 30-norfriedelane 三萜类化合物，即海藻内酯 C ( 1 ) 和海藻酸 ( 2 ) 以及 16 种已知化合物 ( 3 – 18 )。吉尔格（Achariaceae）。所有分离的化合物的结构均已借助广泛的光谱分析（1D 和 2D-​​NMR）以及质谱法确定。筛选了六种化合物 ( 1 – 5 , 9 ) 针对两种菌株恶性疟原虫Dd2 和恶性疟原虫3D7 的抗疟原虫活性。结果表明，海藻酸 ( 2 ) 是最活跃的一种，对Pf Dd2 和Pf 3D7 的 IC ₅₀值分别为 (3.5 ± 0.1 μg/mL) 和 (4.6 ± 0.7 μg/mL)，而青藻内酯 C ( 1 ) 中度抑制Pf Dd2 (9.4 ± 0.1 μg/mL) 和弱Pf 3D7 (15.9 ± 2.3 μg/mL)。分离化合物的分子对接分析表明，化合物1 – 4和9 – 11是潜在的药物靶点，并得到了他们的 ADMET 研究的进一步支持，该研究揭示了百岁内酯 B 和 C（4和5）以及β -谷甾醇（10）作为最有资格作为药物安全的化合物。结果表明，青色念珠菌是新抗疟原虫药物开发中良好候选药物的重要来源。