Oxysterol-binding protein (OSBP) mediates lipid exchange between organelles at membrane contact sites, thereby regulating lipid dynamics and homeostasis. How OSBP's lipid transfer function impacts health and disease remain to be elucidated. In this review, we first summarize the structural characteristics and lipid transport functions of OSBP, and then focus on recent progresses linking OSBP with fatty liver disease, diabetes, lysosome-related diseases, cancer and viral infections, with the aim of discovering novel therapeutic strategies for common human diseases.

中文翻译：

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氧甾醇结合蛋白：脂质转运功能和人类疾病的新见解

氧甾醇结合蛋白（OSBP）介导膜接触位点细胞器之间的脂质交换，从而调节脂质动态和稳态。OSBP 的脂质转移功能如何影响健康和疾病仍有待阐明。本文首先总结了OSBP的结构特征和脂质转运功能，然后重点介绍了OSBP与脂肪肝、糖尿病、溶酶体相关疾病、癌症和病毒感染相关疾病的最新进展，旨在发现新的治疗策略对于人类常见疾病。